6-[4-(3,4-dichlorophenyl)piperazin-1-yl]-7H-purine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 6-[4-(3,4-dichlorophenyl)piperazin-1-yl]-7H-purine
• 化学式: C₁₅H₁₄Cl₂N₆
• 分子量: 349.2
• InChiKey: QVBFELMJIOAJLK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  60.9
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Methods of using MEK inhibitors
  申请人：Lamb Peter

  公开号：US20080166359A1

  公开（公告）日：2008-07-10

  The present invention provides methods of treating cancer by administering a compound of Formula I, or a pharmaceutically acceptable salt or solvate thereof, in combination with other cancer treatments.

  本发明提供了一种通过给予I式化合物或其药学上可接受的盐或溶剂与其他癌症治疗相结合的方法来治疗癌症的方法。
• METHODS OF USING MEK INHIBITORS
  申请人：Exelixis, Inc.

  公开号：EP2101759A1

  公开（公告）日：2009-09-23
• Kinase Modulators and Methods of Use
  申请人：Anand Neel K.

  公开号：US20080076774A1

  公开（公告）日：2008-03-27

  The present invention relates to compounds of the Formula (I) and (II) wherein R, R 21 , R 25 -R 33 , m, n, X 21 -X 23 , and Q 1 are defined herein. The compounds modulate protein kinase enzymatic activity to modulate cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly p70S6 and/or Akt kinases. Methods of using and preparing the compounds, and pharmaceutical compositions thereof, to treat kinase-dependent diseases and conditions are also an aspect of the invention.
• US7999006B2
  申请人：——

  公开号：US7999006B2

  公开（公告）日：2011-08-16
• US8076338B2
  申请人：——

  公开号：US8076338B2

  公开（公告）日：2011-12-13