1-[(Z)-13-oxotetradec-5-enyl]-3-pentylurea

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 英文名称: 1-[(Z)-13-oxotetradec-5-enyl]-3-pentylurea
• 化学式: C₂₀H₃₈N₂O₂
• 分子量: 338.5
• InChiKey: KDKHGFCQOUUQES-VURMDHGXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  24
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• EPOXYEICOSATRIENOIC ACID ANALOGS AND METHODS OF MAKING AND USING THE SAME
  申请人：Imig John David

  公开号：US20140113884A1

  公开（公告）日：2014-04-24

  Compounds and compositions comprising epoxyeicosatrienoic acid (EET) analogs that act as EET agonists and are useful as medications in the treatment of drug-induced nephrotoxicity, hypertension and other related conditions. Methods of making and using the compounds and compositions are further described.

  本发明涉及含有环氧三烯酸（EET）类似物的化合物和组合物，其作为EET激动剂，并且可用作治疗药物，用于治疗药物引起的肾毒性、高血压和其他相关疾病。本文进一步描述了制备和使用这些化合物和组合物的方法。
• KIDNEY-TARGETED EPOXYEICOSATRIENOIC ACID (EET) ANALOGS
  申请人：THE MEDICAL COLLEGE OF WISCONSIN, INC.

  公开号：US20200255433A1

  公开（公告）日：2020-08-13

  Described here are EET analogs conjugated to folate receptor ligands such as folic acid or folic acid analogs recognized by and selectively bound by folate receptors and other folate binding proteins and the use of such conjugated EET analogs for targeted delivery of therapeutic agents to folate-receptor bearing cell populations. More particularly, provided herein are EET analogs conjugated to folate receptor ligands and uses of such conjugated EET analogs as kidney targeted therapeutics.
• US9127027B2
  申请人：——

  公开号：US9127027B2

  公开（公告）日：2015-09-08
• US9422318B2
  申请人：——

  公开号：US9422318B2

  公开（公告）日：2016-08-23