4-Propan-2-yl-1,2,3-benzothiadiazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻二唑类
• 英文名称: 4-Propan-2-yl-1,2,3-benzothiadiazole
• 英文别名: 4-propan-2-yl-1,2,3-benzothiadiazole
• 化学式: C₉H₁₀N₂S
• 分子量: 178.26
• InChiKey: UCYACBDYCVYIEC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] NEW SUBSTITUTED BENZONAPHTHATHIOPHENE COMPOUNDS FOR ORGANIC ELECTRONICS<br/>[FR] NOUVEAUX COMPOSÉS BENZONAPHTATHIOPHÈNES SUBSTITUÉS POUR ÉLÉMENTS ÉLECTRONIQUES ORGANIQUES
  申请人：BASF SE

  公开号：WO2019076709A1

  公开（公告）日：2019-04-25

  The present invention provides compounds of formulae (1) (2) wherein R1and R2are C1-30alkyl, C2-3O-alkenyl, C2-30-alkynyl, C5-7-cycloalkyl, C6-14-aryl or 5 to 14 membered heteroaryl, wherein C1-30-alkyl, C2-3O-alkenyl and C2-3O-alkynyl can be substituted with one or more substituents selected from the group consisting of halogen, phenyl, O-C1-20-alkyl, O-C2-20-alkenyl and O- C2-2O-alkynyl, and wherein C5-7-cycloalkyl, C6-14-aryl and 5 to 14 membered heteroaryl can be substituted with one or more substituents selected from the group consisting of halogen, C1-20alkyl, C2-2O-alkenyl, C2-2O-alkynyl, O-C1-20-alkyl, O-C2-2o-alkenyl and O-C2-2o-alkynyl, Ra, Rb, Rcand Rdare independently and at each occurrence selected from the group consisting of C1-30alkyl, C2-30-alkenyl, C2-30-alkynyl, C6-14-aryl and 5 to 14 membered heteroaryl, wherein C1-30-alkyl, C2-3o-alkenyl and C2-3o-alkynyl can be substituted with one or more substituents selected from the group consisting of halogen, phenyl, O-C1-20-alkyl, O-C2-20-alkenyl and O- C2-20-alkynyl, and wherein C5-7-cycloalkyl, C6-14-aryl and 5 to 14 membered heteroaryl can be substituted with one or more substituents selected from the group consisting of halogen, C1-20alkyl, C2-2o-alkenyl, C2-20-alkynyl, O-C1-20-alkyl, O-C2-20-alkenyl and O-C2-2o-alkynyl, n and o are independently 0, 1, 2, 3, 4 or 5, and m and p are independently 0, 1, 2 or 3, and to electronic device comprising the compounds of formulae 1 or 2.

  本发明提供了公式（1）（2）的化合物，其中R1和R2为C1-30烷基，C2-3O-烯基，C2-30炔基，C5-7环烷基，C6-14芳基或5至14个成员的杂芳基，其中C1-30烷基，C2-3O-烯基和C2-3O-炔基可以被选自卤素，苯基，O-C1-20-烷基，O-C2-20-烯基和O-C2-2O-炔基的一种或多种取代基所取代，而C5-7环烷基，C6-14芳基和5至14个成员的杂芳基可以被选自卤素，C1-20烷基，C2-2O-烯基，C2-2O-炔基，O-C1-20-烷基，O-C2-2O-烯基和O-C2-2O-炔基的一种或多种取代基所取代，Ra，Rb，Rc和Rd分别独立地在每次出现时从C1-30烷基，C2-30-烯基，C2-30-炔基，C6-14芳基和5至14个成员的杂芳基中选取，其中C1-30烷基，C2-3O-烯基和C2-3O-炔基可以被选自卤素，苯基，O-C1-20-烷基，O-C2-20-烯基和O- C2-20-炔基的一种或多种取代基所取代，而C5-7环烷基，C6-14芳基和5至14个成员的杂芳基可以被选自卤素，C1-20烷基，C2-2O-烯基，C2-20-炔基，O-C1-20-烷基，O-C2-20-烯基和O-C2-2o-炔基的一种或多种取代基所取代，n和o分别独立地为0、1、2、3、4或5，而m和p分别独立地为0、1、2或3，并且包括公式1或2的化合物的电子设备。
• SUBSTITUTED PICOLINAMIDE KINASE INHIBITORS
  申请人：Portola Pharmaceuticals, Inc.

  公开号：US20140113931A1

  公开（公告）日：2014-04-24

  Provided are picolinamide compounds for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibiting Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity.

  提供了用于抑制Syk激酶的吡啶甲酰胺化合物，制备这种化合物所使用的中间体，制备这种化合物的方法，制备药物组成物的方法，抑制Syk激酶活性的方法以及治疗至少部分通过Syk激酶活性介导的疾病的方法。
• BICYCLIC OXA-LACTAM KINASE INHIBITORS
  申请人：PORTOLA PHARMACEUTICALS, INC.

  公开号：US20150252056A1

  公开（公告）日：2015-09-10

  Provided are bicyclic oxa-lactam compounds for inhibition of JAK/Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibiting JAK/Syk kinase activity, and methods for treating conditions mediated at least in part by JAK/Syk kinase activity.

  提供了双环氧内酰胺化合物，用于抑制JAK/Syk激酶，用于制备这种化合物的中间体，其制备方法，制备这种化合物的制药组合物，抑制JAK/Syk激酶活性的方法，以及治疗至少部分由JAK/Syk激酶活性介导的疾病的方法。
• BICYCLIC DIHYDROPYRIDONE KINASE INHIBITORS
  申请人：PORTOLA PHARMACEUTICALS, INC.

  公开号：US20150266871A1

  公开（公告）日：2015-09-24

  Provided are bicyclic dihydropyridone compounds for inhibiting of JAK/Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibiting JAK/Syk kinase activity, and methods for treating conditions mediated at least in part by JAK/Syk kinase activity.

  提供了用于抑制JAK/Syk激酶的双环二氢吡啶酮化合物，用于制备这种化合物的中间体，其制备方法，药物组合物，抑制JAK/Syk激酶活性的方法，以及治疗至少部分由JAK/Syk激酶活性介导的疾病的方法。
• HETEROACENES FOR ORGANIC ELECTRONICS
  申请人：BASF SE

  公开号：EP3110807B1

  公开（公告）日：2019-01-09