5-chloro-N-[2-[(2,4-dimethyl-1H-indol-5-yl)oxy]-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-1,3-thiazol-2-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 5-chloro-N-[2-[(2,4-dimethyl-1H-indol-5-yl)oxy]-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-1,3-thiazol-2-amine
• 化学式: C₂₂H₂₄ClN₇OS
• 分子量: 470.0
• InChiKey: VIDVTEWHSAXNPS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  110
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Substituted indol-5-ol derivatives and their therapeutic applications
  申请人：NantBioScience, Inc.

  公开号：US10245261B2

  公开（公告）日：2019-04-02

  The present invention relates generally to the use of compounds to treat a variety of disorders, diseases and pathologic conditions and more specifically to the use of substituted indol-5-ol derivatives to modulate protein kinases and for treating protein kinase-mediated diseases.

  本发明一般涉及使用化合物治疗各种失调、疾病和病理状况，更具体地说，涉及使用取代的吲哚-5-醇衍生物调节蛋白激酶和治疗蛋白激酶介导的疾病。
• [EN] SUBSTITUTED INDOL-5-OL DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS<br/>[FR] DÉRIVÉS INDOL-5-OLE SUBSTITUÉS ET LEURS APPLICATIONS THÉRAPEUTIQUES
  申请人：NANT HOLDINGS IP LLC

  公开号：WO2014071378A9

  公开（公告）日：2015-02-05
• SUBSTITUTED INDOL-5-OL DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS
  申请人：NANT HOLDINGS IP, LLC

  公开号：US20150291564A1

  公开（公告）日：2015-10-15

  The present invention relates generally to the use of compounds to treat a variety of disorders, diseases and pathologic conditions and more specifically to the use of substituted indol-5-ol derivatives to modulate protein kinases and for treating protein kinase-mediated diseases.
• SUBSTITUTED INDOL-5-OL DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS
  申请人：NANTBIOSCIENCE, INC

  公开号：US20160016945A1

  公开（公告）日：2016-01-21

  The present invention relates generally to the use of compounds to treat a variety of disorders, diseases and pathologic conditions and more specifically to the use of substituted indol-5-ol derivatives to modulate protein kinases and for treating protein kinase-mediated diseases.
• US9458137B2
  申请人：——

  公开号：US9458137B2

  公开（公告）日：2016-10-04