[(2S,5R)-5-(2,6-diaminopurin-9-yl)oxolan-2-yl]methyl dihydrogen phosphate

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 英文名称: [(2S,5R)-5-(2,6-diaminopurin-9-yl)oxolan-2-yl]methyl dihydrogen phosphate
• 化学式: C₁₀H₁₅N₆O₅P
• 分子量: 330.24
• InChiKey: YSVGKSFASYRYCB-NTSWFWBYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  172
• 氢给体数：
  4
• 氢受体数：
  10

文献信息

• NEW PHOSPHODEOXYRIBOSYLTRANSFERASE MUTANT ENZYMES AND USES THEREOF
  申请人：Centre National de la Recherche Scientifique (C.N.R.S.)

  公开号：EP2917341B1

  公开（公告）日：2017-09-27
• [EN] NEW PHOSPHODEOXYRIBOSYLTRANSFERASE MUTANT ENZYMES AND USES THEREOF<br/>[FR] NOUVELLES ENZYMES MUTANTES PHOSPHODÉSOXYRIBOSYLTRANSFÉRASES ET LEURS UTILISATIONS
  申请人：CENTRE NAT RECH SCIENT

  公开号：WO2014072487A1

  公开（公告）日：2014-05-15

  The present invention relates to enzyme mutants obtained from the nucleoside deoxyribosyltransferase (NDT) of Lactobacilli bacteria. These mutants are surprisingly able to exchange deoxyribose mono-, bi- and triphosphate between various nucleobases. In vitro syntheses have been successfully performed with several nucleobase analogs. These enzyme mutants provide new tools to synthesize, in vitro and/or in vivo, dNTPs or analogs thereof.
• [EN] CYCLIC DINUCLEOTIDE STING AGONISTS FOR CANCER TREATMENT<br/>[FR] AGONISTES DINUCLÉOTIDIQUES CYCLIQUES DE STING POUR LE TRAITEMENT DU CANCER
  申请人：MERCK SHARP & DOHME

  公开号：WO2018118665A1

  公开（公告）日：2018-06-28

  Therapies comprising administering at least one cyclic dinucleotide compound that activates the Stimulator of Interferon Genes (STING) pathway, and the use of such therapies in the treatment of cell-proliferation disorders such as cancer, are disclosed herein.
• [EN] CYCLIC DINUCLEOTIDES AS STING AGONISTS<br/>[FR] DINUCLÉOTIDES CYCLIQUES EN TANT QU'AGONISTES STING
  申请人：JANSSEN BIOTECH INC

  公开号：WO2020016782A1

  公开（公告）日：2020-01-23

  Disclosed are compounds, compositions and methods for treating of diseases, syndromes, or disorders that are affected by the modulation of STING. Such compounds are represented by Formula (I), wherein R1, R1', X1, B1, R2, R2', B2, X2, R3, Z-M-Y, and Y1-M1-Z1 are as defined herein.