4-(Methoxymethyl)-6-methyl-2-{[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]sulfanyl}pyridine-3-carbonitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-(Methoxymethyl)-6-methyl-2-{[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]sulfanyl}pyridine-3-carbonitrile
• 英文别名: 4-(methoxymethyl)-6-methyl-2-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]sulfanylpyridine-3-carbonitrile
• 化学式: C₂₁H₂₄N₄O₂S
• 分子量: 396.5
• InChiKey: YCUSRKVUFQNICY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  94.8
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• DIARYLPYRIDINE ANTI-VIRAL COMPOUNDS
  申请人：Kineta, Inc.

  公开号：EP2977085A1

  公开（公告）日：2016-01-27

  Disclosed herein are compounds and related compositions for the treatment of viral infection, including RNA viral infection, and compounds that can modulate the RIG-I pathway in vertebrate cells, including compounds that can activate the RIG-I pathway.

  本文披露了用于治疗病毒感染的化合物和相关组合物，包括RNA病毒感染，并且可以调节脊椎动物细胞中的RIG-I途径的化合物，包括可以激活RIG-I途径的化合物。
• Anti-Viral Compounds
  申请人：Iadonato Shawn P.

  公开号：US20130039944A1

  公开（公告）日：2013-02-14

  Disclosed herein are compounds and related compositions for the treatment of viral infection, including RNA viral infection, and compounds that can modulate the RIG-I pathway in vertebrate cells, including compounds that can activate the RIG-I pathway.
• US9301952B2
  申请人：——

  公开号：US9301952B2

  公开（公告）日：2016-04-05
• [EN] ANTI-VIRAL COMPOUNDS<br/>[FR] COMPOSÉS ANTIVIRAUX
  申请人：KINETA INC

  公开号：WO2011133727A2

  公开（公告）日：2011-10-27

  Disclosed herein are compounds and related compositions for the treatment of viral infection, including RNA viral infection, and compounds that can modulate the RIG-I pathway in vertebrate cells, including compounds that can activate the RIG-I pathway.