2,2-Difluoroethyl 2-ethoxycarbonyloxyacetate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 英文名称: 2,2-Difluoroethyl 2-ethoxycarbonyloxyacetate
• 英文别名: 2,2-difluoroethyl 2-ethoxycarbonyloxyacetate
• 化学式: C₇H₁₀F₂O₅
• 分子量: 212.15
• InChiKey: DAPFKMZOALJUTG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  14
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• BIODEGRADABLE POLYMERS, COMPLEXES THEREOF FOR GENE THERAPEUTICS AND DRUG DELIVERY, AND METHODS RELATED THERETO
  申请人：International Business Machines Corporation

  公开号：EP2516504B1

  公开（公告）日：2015-12-02
• [EN] POLYCARBONATES BEARING AROMATIC N-HETEROCYCLES FOR DRUG DELIVERY<br/>[FR] POLYCARBONATES PORTANT DES N-HÉTÉROCYCLES AROMATIQUES POUR L'ADMINISTRATION D'UN MÉDICAMENT
  申请人：IBM

  公开号：WO2015083377A1

  公开（公告）日：2015-06-11

  Nanoparticles comprise a drug, a first block polymer and a second block polymer. The first block polymer has a poly(ethylene oxide) (PEO) block and a polycarbonate block bearing a side chain aromatic nitrogen-containing heterocycle (N-heterocycle). The N-heterocycle can be in the form of a base, a hydrosalt of the base, a sulfobetaine adduct of the base, or a combination thereof. The second block polymer has a PEO block and a polycarbonate block bearing a side chain catechol group, which can be present as a catechol, oxidized form of a catechol, and/or a polymerized form of a catechol. The nanoparticles can be dispersed in water and are capable of controlled release of the drug.
• [EN] WATER SOLUBLE POLYCARBONATES FOR MEDICAL APPLICATIONS<br/>[FR] POLYCARBONATES SOLUBLES DANS L'EAU POUR APPLICATIONS MÉDICALES
  申请人：IBM

  公开号：WO2016055880A1

  公开（公告）日：2016-04-14

  Water soluble biodegradable polymers were prepared by an organoacid catalyzed ring opening polymerization (ROP) of a cyclic carbonate monomer bearing an active ester side chain. The initial polymer comprising an active ester side chain was treated with an amino-alcohol, which transformed the active ester groups to N-substituted amide groups bearing mono-hydroxy alkyl groups and/or dihydroxy alkyl groups, thereby forming the water soluble polymers. The water- soluble polymers are non-toxic and exhibit stealth properties in buffered serum solution.
• [EN] FLUORO-ALCOHOL ADDITIVES FOR ORIENTATION CONTROL OF BLOCK COPOLYMERS<br/>[FR] ADDITIFS FLUORO-ALCOOL POUR COMMANDER L'ORIENTATION DE COPOLYMÈRES SÉQUENCÉS
  申请人：IBM

  公开号：WO2016132247A1

  公开（公告）日：2016-08-25

  A film layer comprising a high-chi (ϰ) block copolymer for self-assembly and a hexafluoroalcohol-containing surface active polymer (SAP) was prepared on a substrate surface that was neutral wetting to the domains of the self-assembled block copolymer. The block copolymer comprises at least one polycarbonate block and at least one other block (e.g., a substituted or unsubstituted styrene-based block). The film layer, whose top surface has contact with an atmosphere, self-assembles to form a lamellar or cylindrical domain pattern having perpendicular orientation with respect to the underlying surface. Other morphologies (e.g., islands and holes of height 1.0Lo) were obtained with films lacking the SAP. The SAP is preferentially miscible with, and lowers the surface energy of, the domain comprising the polycarbonate block.