N-(3,4-dichlorophenyl)-4-(pyrimidin-2-yl)piperazine-1-carbothioamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: N-(3,4-dichlorophenyl)-4-(pyrimidin-2-yl)piperazine-1-carbothioamide
• 英文别名: N-(3,4-dichlorophenyl)-4-pyrimidin-2-ylpiperazine-1-carbothioamide
• 化学式: C₁₅H₁₅Cl₂N₅S
• 分子量: 368.3
• InChiKey: DGGTYGHRDYFFLC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  76.4
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• NOVEL COMPOUNDS
  申请人：Priepke Henning

  公开号：US20120309738A1

  公开（公告）日：2012-12-06

  This invention relates to compounds of formula I their use as inhibitors of the microsomal prostaglandin E 2 synthase-1 (mPGES-1), to pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions. A, M, W, R 1 , R 2 , R 3 , R 4 , R 6 , R 2 , R 7 , R 8 , R 9 , R a , R b have meanings given in the description.

  这项发明涉及公式I化合物，它们作为微粒体前列腺素E2合酶-1（mPGES-1）的抑制剂的用途，含有它们的药物组合物，以及它们作为治疗和/或预防炎症性疾病和相关症状的药物的用途。A、M、W、R1、R2、R3、R4、R6、R2、R7、R8、R9、Ra、Rb在描述中有给定的含义。
• 2-AMINOBENZIMIDAZOLE DERIVATIVES USEFUL IN THE TREATMENT OF INFLAMMATION
  申请人：Boehringer Ingelheim International GmbH

  公开号：EP2649052B1

  公开（公告）日：2014-10-22
• Anti-Arenaviral Compounds
  申请人：Amberg Sean M.

  公开号：US20120308519A1

  公开（公告）日：2012-12-06

  Described herein are 4-methyl-piperazine-1-carbothioic acid amide derivatives and analogs, as well as compositions containing the same, for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by hemorrhagic fever viruses, such as Arenaviruses.
• ANTI-ARENAVIRAL COMPOUNDS
  申请人：SIGA TECHNOLOGIES, INC.,

  公开号：US20140301979A1

  公开（公告）日：2014-10-09

  Described herein are 4-methyl-piperazine-1-carbothioic acid amide derivatives and analogs, as well as compositions containing the same, for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by hemorrhagic fever viruses, such as Arenaviruses.
• US8466186B2
  申请人：——

  公开号：US8466186B2

  公开（公告）日：2013-06-18