tert-butyl 4-(4-(7-(2,6-difluorophenylamino)-4-oxo-3,4-dihydropyrido[3,4-d]pyridazin-5-ylamino)-3-methoxyphenyl)piperazine-1-carboxylate | 1390656-94-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: tert-butyl 4-(4-(7-(2,6-difluorophenylamino)-4-oxo-3,4-dihydropyrido[3,4-d]pyridazin-5-ylamino)-3-methoxyphenyl)piperazine-1-carboxylate
• 英文别名: tert-butyl 4-[4-[[7-(2,6-difluoroanilino)-4-oxo-3H-pyrido[3,4-d]pyridazin-5-yl]amino]-3-methoxyphenyl]piperazine-1-carboxylate
• CAS: 1390656-94-6
• 化学式: C₂₉H₃₁F₂N₇O₄
• 分子量: 579.606
• InChiKey: SHLQVNGMNOMEOP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  42
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  120
• 氢给体数：
  3
• 氢受体数：
  11

文献信息

• BICYCLIC INHIBITORS OF ALK
  申请人：Vasudevan Anil

  公开号：US20140155389A1

  公开（公告）日：2014-06-05

  The present invention relates to compounds of formula (1) or pharmaceutical acceptable salts, wherein R 1 , X, Y, Z, A, B, G 1 , and n are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as ALK and methods of treating diseases such as cancer.

  本发明涉及公式（1）的化合物或药物可接受的盐，其中R1、X、Y、Z、A、B、G1和n在说明书中有定义。本发明还涉及含有所述化合物的组合物，其对抑制激酶如ALK具有用处，以及用于治疗癌症等疾病的方法。
• NON-AQUEOUS ELECTROLYTE AND ELECTRICITY STORAGE DEVICE USING SAME
  申请人：UBE Industries, Ltd.

  公开号：EP2744030A1

  公开（公告）日：2014-06-18

  The present invention provides a nonaqueous electrolytic solution capable of improving electrochemical characteristics in a broad temperature range, such as low-temperature cycle properties and low-temperature discharge properties after high-temperature storage, and provides an energy storage device using the nonaqueous electrolytic solution. The invention includes (1) a nonaqueous electrolytic solution of an electrolyte salt dissolved in a nonaqueous solvent, which comprises from 0.001 to 10% by mass of a compound represented by the following general formula (I), and (2) an energy storage device comprising a positive electrode, a negative electrode, and a nonaqueous electrolytic solution of an electrolyte salt dissolved in a nonaqueous solvent, wherein the nonaqueous electrolytic solution is the nonaqueous electrolytic solution of (1). (In the formula, Y represents a group -C(=O)- or a group -S(=O)2-; R3 and R4 each independently represent an aryl group having from 6 to 10 carbon atoms in which at least one hydrogen atom is substituted with a halogen atom, or R3 and R4 bonding to each other represent a cycloalkanediyl group or a benzenediyl group, having from 5 to 12 carbon atoms. R represents -C(R1)(R2)- or -L-; R1 and R2 each independently represent a hydrogen atom, a halogen atom, or an alkyl group having from 1 to 4 carbon atoms; and L represents a divalent linking group having from 1 to 6 carbon atoms and optionally substituted with a halogen atom.)

  本发明提供了一种非水性电解溶液，能够改善在宽温度范围内的电化学特性，例如低温循环特性和高温储存后的低温放电特性，并提供了一种使用该非水性电解溶液的储能装置。本发明包括：（1）溶解在非水溶剂中的电解质盐的非水性电解溶液，该溶液包含 0.001 至 10%（按质量计）由以下通式（I）表示的化合物；（2）一种储能装置，该装置包括正极、负极和溶解在非水溶剂中的电解质盐的非水性电解溶液，其中非水性电解溶液是（1）的非水性电解溶液。 (式中，Y 代表-C(＝O)-基团或-S(＝O)2-基团；R3 和 R4 各自独立地代表具有 6 至 10 个碳原子的芳基，其中至少一个氢原子被卤原子取代，或 R3 和 R4 相互结合代表具有 5 至 12 个碳原子的环烷二基或苯二基。R 代表-C(R1)(R2)-或-L-；R1 和 R2 各自独立地代表氢原子、卤素原子或具有 1 至 4 个碳原子的烷基；L 代表具有 1 至 6 个碳原子并可选地被卤素原子取代的二价连接基团)。
• US9236635B2
  申请人：——

  公开号：US9236635B2

  公开（公告）日：2016-01-12