(3S)-3-ethyl-1-[4-(fluoromethyl)-1-benzofuran-7-yl]piperazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (3S)-3-ethyl-1-[4-(fluoromethyl)-1-benzofuran-7-yl]piperazine
• 化学式: C₁₅H₁₉FN₂O
• 分子量: 262.32
• InChiKey: NAAOAQJIWVJGET-LBPRGKRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  28.4
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• FUSED HETEROCYCLIC COMPOUND AND USE THEREOF
  申请人：Takeda Pharmaceutical Company Limited

  公开号：US20150238506A1

  公开（公告）日：2015-08-27

  The present invention relates to a serotonin 5-HT 2C receptor activator containing a compound represented by the formula wherein ring A is a 5- or 6-membered aromatic heterocycle optionally having substituent(s), and ring B is a 7- to 9-membered ring optionally having substituent(s) other than an oxo group wherein the combination of m and n (m,n) is (1,2), (2,1), (2,2), (3,1), (3,2) or (4,1), or a salt thereof or a prodrug thereof, and a fused heterocyclic compound having a serotonin 5-HT 2C receptor activating action and the like.

  本发明涉及一种包含由式表示的化合物的5-羟色胺5-HT2C受体激活剂，其中环A是一个5-或6-成员芳香杂环，可选地具有取代基，环B是一个7-至9-成员环，可选地具有除氧基以外的取代基，其中m和n的组合（m，n）为（1,2），（2,1），（2,2），（3,1），（3,2）或（4,1），或其盐或前药，以及具有5-羟色胺5-HT2C受体激活作用的融合杂环化合物等。
• PREVENTIVES/REMEDIES FOR STRESS URINARY INCONTINENCE AND METHOD OF SCREENING THE SAME
  申请人：Takeda Pharmaceutical Company Limited

  公开号：US20140155369A1

  公开（公告）日：2014-06-05

  An agent for the prophylaxis or treatment of stress urinary incontinence, which contains a substance that activates a serotonin 5-HT 2C receptor, an agent for the prophylaxis or treatment of stress urinary incontinence, which contains a substance that stimulates an androgen binding site, and a method of screening for a drug for the prophylaxis or treatment of abdominal pressure incontinence, which includes electrostimulating the abdominal muscles or a nerve controlling them of an animal to increase the abdominal pressure, and measuring the leak point pressure at that time.
• US9079907B2
  申请人：——

  公开号：US9079907B2

  公开（公告）日：2015-07-14