1-[1-(1-Sulfooxyethyl)piperazin-1-ium-1-yl]ethyl hydrogen sulfate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-[1-(1-Sulfooxyethyl)piperazin-1-ium-1-yl]ethyl hydrogen sulfate
• 英文别名: 1-[1-(1-sulfooxyethyl)piperazin-1-ium-1-yl]ethyl hydrogen sulfate
• 化学式: C8H19N2O8S2+
• 分子量: 335.4
• InChiKey: JNAUBOXIQRXZDR-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  -3.7
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  156
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• Methods and Compositions for Treating Conditions of the Eye
  申请人：Massachusetts Eye and Ear Infirmary

  公开号：US20140163451A1

  公开（公告）日：2014-06-12

  Provided are methods and compositions for the photodynamic therapy (PDT) of ocular conditions characterized by the presence of unwanted choroidal neovasculature, for example, neovascular age-related macular degeneration. The selectivity and sensitivity of the PDT method can be enhanced by combining the PDT with an anti-angiogenesis factor, for example, angiostatin or endostatin, or with an apoptosis-modulating factor. Furthermore, the selectivity and sensitivity of the PDT may be further enhanced by coupling a targeting moiety to the photosensitizer so as to target the photosensitizer to choroidal neovasculature.