Tert-butyl 4-[(5-chloro-2-methyl-3-nitrophenyl)methyl]-2-methylpiperazine-1-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: Tert-butyl 4-[(5-chloro-2-methyl-3-nitrophenyl)methyl]-2-methylpiperazine-1-carboxylate
• 英文别名: tert-butyl 4-[(5-chloro-2-methyl-3-nitrophenyl)methyl]-2-methylpiperazine-1-carboxylate
• 化学式: C18H26ClN3O4
• 分子量: 383.9
• InChiKey: DLEUXLJMIZVCEQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  78.6
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• MODULATORS OF THE RETINOID-RELATED ORPHAN RECEPTOR GAMMA (ROR-GAMMA) FOR USE IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISEASES
  申请人：GLAXO GROUP LIMITED

  公开号：US20150299121A1

  公开（公告）日：2015-10-22

  The present invention relates to novel retinoid-related orphan receptor gamma (RORγ) modulators and their use in the treatment of diseases mediated by RORγ.

  本发明涉及新型视黄醇相关孤儿受体γ（RORγ）调节剂及其在治疗由RORγ介导的疾病中的应用。
• Modulators of the retinoid-related orphan receptor gamma (ROR-gamma) for use in the treatment of autoimmune and inflammatory diseases
  申请人：Glaxo Group Limited

  公开号：US10005731B2

  公开（公告）日：2018-06-26

  The present invention relates to novel retinoid-related orphan receptor gamma (RORγ) modulators and their use in the treatment of diseases mediated by RORγ.

  本发明涉及新型视黄醇相关孤儿受体γ（RORγ）调节剂及其在治疗由 RORγ 介导的疾病中的用途。
• PIPERAZINE DERIVATIVES AS ROR-GAMMA MODULATORS
  申请人：GlaxoSmithKline Intellectual Property Development Limited

  公开号：EP3148975B1

  公开（公告）日：2018-11-28
• NOVEL COMPOUNDS
  申请人：GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

  公开号：US20170101399A1

  公开（公告）日：2017-04-13

  The present invention relates to novel retinoid-related orphan receptor gamma (RORγ) modulators and their use in the treatment of diseases mediated by RORγ
• US9868724B2
  申请人：——

  公开号：US9868724B2

  公开（公告）日：2018-01-16