1-[3-(Trifluoromethoxy)benzyl]piperidin-4-amine | 380424-86-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-[3-(Trifluoromethoxy)benzyl]piperidin-4-amine
• 英文别名: 1-[[3-(trifluoromethoxy)phenyl]methyl]piperidin-4-amine
• CAS: 380424-86-2
• 化学式: C₁₃H₁₇F₃N₂O
• mdl: MFCD20755172
• 分子量: 274.286
• InChiKey: AZKBUVHNMXVVIQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  38.5
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1-[3-(Trifluoromethoxy)benzyl]piperidin-4-amine 以 乙醇 为溶剂， 反应 24.0h， 生成
  参考文献：
  名称：

  THE DESIGN AND SYNTHESIS OF PURINE INHIBITORS OF CDK2. III

  摘要：

  Cyclin-dependent kinases (CDKs) belong to a class of enzymes that control the ability of a cell to enter into and proceed through the cell division cycle. Using purine as a scaffold, we have synthesized a number of nanomolar inhibitors of CDK-2/cyclin E. In this report, the synthesis of a series of piperidine-substituted purine analogs will be presented, as well as some of their in vitro and in vivo biological effects.

  DOI：

  10.1081/ncn-100002493
• 作为产物：
  描述：

  1-[[3-(trifluoromethoxy)phenyl]methyl]piperidine-4-carboxamide 在 [双(三氟乙酰氧基)碘]苯 作用下， 以 水 、 乙腈 为溶剂， 生成 1-[3-(Trifluoromethoxy)benzyl]piperidin-4-amine
  参考文献：
  名称：

  THE DESIGN AND SYNTHESIS OF PURINE INHIBITORS OF CDK2. III

  摘要：

  Cyclin-dependent kinases (CDKs) belong to a class of enzymes that control the ability of a cell to enter into and proceed through the cell division cycle. Using purine as a scaffold, we have synthesized a number of nanomolar inhibitors of CDK-2/cyclin E. In this report, the synthesis of a series of piperidine-substituted purine analogs will be presented, as well as some of their in vitro and in vivo biological effects.

  DOI：

  10.1081/ncn-100002493

文献信息

• [EN] THIA(DIA)ZOLES AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS<br/>[FR] THIA(DIA)ZOLES EN TANT QU'ANTAGONISTES DU RÉCEPTEUR DE LA DOPAMINE À DISSOCIATION RAPIDE
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2008128996A1

  公开（公告）日：2008-10-30

  [EN] The present invention relates to [1- (benzyl) -piperidin-4-yl] -( [1, 3,4] thiadiazol-2-yl) - amine and [1- (benzyl) -piperidin-4-yl] - (thiazol-2-yl) -amine derivatives of formula (I) that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disorders, for example schizophrenia, by exerting an antipsychotic effect without motor side effects.
  [FR] Cette invention concerne des dérivés de [1- (benzyl) -pipéridin-4-yl] -( [1, 3,4] thiadiazol-2-yl) - amine et de [1- (benzyl) -pipéridine-4-yl] - (thiazol-2-yl) -amine, représentés par la formule (I), qui sont des antagonistes du récepteur 2 de la dopamine à dissociation rapide, des procédés de préparation de ces composés et des compositions pharmaceutiques contenant ces composés comme principe actif. Ces composés conviennent pour le traitement ou la prévention des troubles du système nerveux central, notamment de la schizophrénie, par l'action anti-psychotique qu'ils exercent sans effets secondaires moteurs.
• THE DESIGN AND SYNTHESIS OF PURINE INHIBITORS OF CDK2. III
  作者：P. W. Shum、N. P. Peet、P. M. Weintraub、T. B. Le、Z. Zhao、F. Barbone、B. Cashman、J. Tsay、S. Dwyer、P. C. Loos、E. A. Powers、K. Kropp、P. S. Wright、A. Bitonti、J. Dumont、D. R. Borcherding

  DOI：10.1081/ncn-100002493

  日期：2001.3.31

  Cyclin-dependent kinases (CDKs) belong to a class of enzymes that control the ability of a cell to enter into and proceed through the cell division cycle. Using purine as a scaffold, we have synthesized a number of nanomolar inhibitors of CDK-2/cyclin E. In this report, the synthesis of a series of piperidine-substituted purine analogs will be presented, as well as some of their in vitro and in vivo biological effects.