4-(5,6-dibromo-4-nitro-1H-benzimidazol-2-yl)piperazine-1-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-(5,6-dibromo-4-nitro-1H-benzimidazol-2-yl)piperazine-1-carboxylate
• 化学式: C12H10Br2N5O4-
• 分子量: 448.05
• InChiKey: CHMSDBTVHSBCPW-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  121
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• NOVEL BENZIMIDAZOLE DERIVATIVES AS KINASE INHIBITORS
  申请人：SELVITA S.A.

  公开号：EP2935244A2

  公开（公告）日：2015-10-28
• [EN] NOVEL BENZIMIDAZOLE DERIVATIVES AS KINASE INHIBITORS<br/>[FR] NOUVEAUX DÉRIVÉS DE BENZIMIDAZOLE EN TANT QU'INHIBITEURS DE LA KINASE
  申请人：SELVITA S A

  公开号：WO2014096388A2

  公开（公告）日：2014-06-26

  The present invention relates to derivatives of benzimidazoles of formula (I) as disclosed herein as well as pharmaceutical compositions comprising said derivatives. The derivates according to the present invention are serine/threonine and tyrosine kinase-inhibitors, particularly of PIM1-3-and DYRK1A-kinases and may particularly be used in the treatment of diseases linked to these kinases, such as e.g. leukemias, lymphomas, solid tumors and autoimmune disorders.