[(E,2R,3S)-2-amino-3-hydroxyoctadec-4-enyl] methyl hydrogen phosphate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 鞘脂
• 英文名称: [(E,2R,3S)-2-amino-3-hydroxyoctadec-4-enyl] methyl hydrogen phosphate
• 化学式: C₁₉H₄₀NO₅P
• 分子量: 393.5
• InChiKey: OFAQIFHMCJSGRI-HIILJQNOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  26
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  102
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• [EN] COMPOSITIONS AND METHODS FOR THE TREATMENT OF METABOLIC DISEASES<br/>[FR] COMPOSITIONS ET MÉTHODES DE TRAITEMENT DE MALADIES MÉTABOLIQUES
  申请人：KANDULA MAHESH

  公开号：WO2015028927A1

  公开（公告）日：2015-03-05

  The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, and methods for the treatment of metabolic diseases may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of depression, liver disease, and the pain of osteoarthritis, cancer, Parkinson's disease, cancer, cardiovascular diseases, diabetes, hyperglycemia and other metabolic diseases which involve deficiency of SAM.

  该发明涉及公式I的化合物或其药用可接受的盐，以及其多晶型、溶剂合物、对映体、立体异构体和水合物。包括公式I化合物的有效量的药物组合物，以及用于治疗代谢疾病的方法可以制成口服、颊下、直肠、局部、经皮、经粘膜、静脉、肠道、糖浆或注射剂形式。这些组合物可以用于治疗抑郁症、肝病、骨关节炎疼痛、癌症、帕金森病、癌症、心血管疾病、糖尿病、高血糖和其他涉及SAM缺乏的代谢性疾病。
• [EN] COMPOSITIONS AND METHODS FOR THE TREATMENT OF SEIZURES AND NEUROLOGIC DISEASES<br/>[FR] COMPOSITIONS ET MÉTHODES DESTINÉES À TRAITER LES AVC ET AUTRES MALADIES NEUROLOGIQUES
  申请人：KANDULA MAHESH

  公开号：WO2014097137A2

  公开（公告）日：2014-06-26

  The invention relates to the compounds of formula I and formula II or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I and formula II, and methods for the treatment of seizures and neurological diseases may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of epileptic seizures, epilepsy, simple and complex seizures.
• [EN] COMPOSITIONS AND METHODS FOR THE TREATMENT OF NEUROLOGICAL DISEASES<br/>[FR] COMPOSITIONS ET PROCÉDÉS DE TRAITEMENT DE MALADIES NEUROLOGIQUES
  申请人：MOHAN M ALAPATI

  公开号：WO2016046675A1

  公开（公告）日：2016-03-31

  The compounds and compositions which includes formula I, formula II, formula III and formula IV or its pharmaceutical acceptable compositions or in a salt form, as well as polymorphs, enantiomers, stereoisomers, solvates, and hydrates thereof. These compounds and compositions may be formulated as pharmaceutical compositions. The pharmaceutical compositions may be formulated for oral administration, transmucosal, syrup, topical, parenteral administration, injection, subdermal, oral solution, rectal administration, nanoparticle, buccal administration or transdermal administration. Such compositions may be used to treatment of neurological diseases or its associated complications.