3-(2,2-Dimethylpropyl)thietane

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 硫杂环丁烷
• 英文名称: 3-(2,2-Dimethylpropyl)thietane
• 英文别名: 3-(2,2-dimethylpropyl)thietane
• 化学式: C₈H₁₆S
• 分子量: 144.28
• InChiKey: LNISBCYQGYICGT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  25.3
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• AZETIDINE DERIVATIVES AS ANTIPARASITIC AGENTS
  申请人：Zoetis LLC

  公开号：US20150119377A1

  公开（公告）日：2015-04-30

  This invention recites substituted azetidine derivatives of Formula (1) stereoisomers thereof, veterinarily acceptable salts thereof, compositions thereof, and their use as a parasiticide in animals. The substituents A, B, R 1a , R 1b , R 1c , R 2 , R 3 , R 4 , R 6 , and n are as described herein.

  本发明涉及一种式（1）的取代氮杂环丙烷衍生物及其立体异构体、兽医可接受的盐、组合物以及它们在动物寄生虫中的使用作为寄生虫杀虫剂。其中取代基A、B、R1a、R1b、R1c、R2、R3、R4、R6和n的定义如本文所述。
• DIHYDROFURAN AZETIDINE DERIVATIVES AS ANTIPARASITIC AGENTS
  申请人：Zoetis LLC

  公开号：US20150038440A1

  公开（公告）日：2015-02-05

  This invention recites dihydrofuran substituted azetidine derivatives of Formula (1) stereoisomers thereof, veterinarily acceptable salts thereof, compositions thereof, and their use as a parasiticide in mammals and birds. The substituents A, R 1a , R 1b , R 1c , R 2 , R 3 , R 4 , R 6 , and n are as described herein.

  本发明涉及一种公式（1）的二氢呋喃取代的氮杂环丙烷衍生物及其立体异构体，其兽医可接受的盐，其组合物以及它们在哺乳动物和鸟类中作为寄生虫杀虫剂的用途。其中，取代基A，R1a，R1b，R1c，R2，R3，R4，R6和n如本文所述。
• ISOXAZOLINE DERIVATIVES AS INSECTICIDAL COMPOUNDS
  申请人：Cassayre Jerome Yves

  公开号：US20140194376A1

  公开（公告）日：2014-07-10

  The present invention provides compounds of formula (I) wherein G 1 is oxygen; R 1 is hydrogen; R 2 is group (P) L is a bond, methylene or ethylene; one of A 1 and A 2 is S, SO or SO 2 and the other is —C(R 4 )R 4 —; R 3 is hydrogen or methyl; each R 4 is independently hydrogen or methyl; Y 2 and Y 3 are independently CH or nitrogen, wherein Y 2 and Y 3 are not both nitrogen; X 2 is C—X 6 or nitrogen; X 1 , X 3 and X 6 are independently hydrogen, halogen or trihalomethyl, wherein at least two of X 1 , X 3 and X 6 are not hydrogen; X 4 is trifluoromethyl, difluoromethyl or chlorodifluoromethyl. The invention also provides intermediates useful for the preparation of compounds of formula (I), as well as methods of controlling insects, acarines, nematodes or molluscs using the compounds of formula (I).

  本发明提供了化合物的公式(I)，其中G1为氧；R1为氢；R2为基团（P）L为键，亚甲基或乙烯基；A1和A2中的一个为S，SO或SO2，另一个为—C（R4）R4—；R3为氢或甲基；每个R4独立地为氢或甲基；Y2和Y3独立地为CH或氮，其中Y2和Y3不同时为氮；X2为C—X6或氮；X1、X3和X6独立地为氢、卤素或三卤甲基，其中至少两个为非氢；X4为三氟甲基、二氟甲基或氯二氟甲基。本发明还提供了用于制备公式(I)化合物的中间体，以及使用公式(I)化合物控制昆虫、螨、线虫或软体动物的方法。
• Arginine methyltransferase inhibitors and uses thereof
  申请人：Epizyme, Inc.

  公开号：US10632103B2

  公开（公告）日：2020-04-28

  Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds described herein are useful for inhibiting arginine methyltransferase activity. Methods of using the compounds for treating arginine methyltransferase-mediated disorders are also described.

  本文描述了式（I）化合物、其药学上可接受的盐及其药物组合物。本文所述化合物可用于抑制精氨酸甲基转移酶活性。还描述了使用这些化合物治疗精氨酸甲基转移酶介导的疾病的方法。
• US9073912B2
  申请人：——

  公开号：US9073912B2

  公开（公告）日：2015-07-07