2-[2,5-Difluoro-3-[2-oxo-2-(prop-2-ynylamino)ethyl]sulfanylphenyl]-11,11,12,19,20,21,21-heptamethyl-16-oxa-7,25-dithia-12,20-diazaheptacyclo[15.11.0.03,15.05,13.06,10.019,27.022,26]octacosa-1,3(15),4,6(10),8,13,17,22(26),23,27-decaene-8,24-disulfonic acid

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 新黄酮类化合物
• 英文名称: 2-[2,5-Difluoro-3-[2-oxo-2-(prop-2-ynylamino)ethyl]sulfanylphenyl]-11,11,12,19,20,21,21-heptamethyl-16-oxa-7,25-dithia-12,20-diazaheptacyclo[15.11.0.03,15.05,13.06,10.019,27.022,26]octacosa-1,3(15),4,6(10),8,13,17,22(26),23,27-decaene-8,24-disulfonic acid
• 英文别名: 2-[2,5-difluoro-3-[2-oxo-2-(prop-2-ynylamino)ethyl]sulfanylphenyl]-11,11,12,19,20,21,21-heptamethyl-16-oxa-7,25-dithia-12,20-diazaheptacyclo[15.11.0.03,15.05,13.06,10.019,27.022,26]octacosa-1,3(15),4,6(10),8,13,17,22(26),23,27-decaene-8,24-disulfonic acid
• 化学式: C₄₁H₃₇F₂N₃O₈S₅
• 分子量: 898.1
• InChiKey: OUSHLEUGICPIPG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  59
• 可旋转键数：
  7
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  252
• 氢给体数：
  3
• 氢受体数：
  15

文献信息

• OLIGOSACCHARIDE MODIFICATION AND LABELING OF PROTEINS
  申请人：LIFE TECHNOLOGIES CORPORATION

  公开号：US20140377837A1

  公开（公告）日：2014-12-25

  The present invention generally relates to methods of functionalizing proteins, particularly antibodies, at oligosaccharide linkages, methods of humanizing antibodies by modifying glycosylation, as well as to novel antibodies linked to modified oligosaccharides. The invention further relates to kits that may be used to produce the antibodies of the invention.
• US8785212B2
  申请人：——

  公开号：US8785212B2

  公开（公告）日：2014-07-22