5-[4-[2-(4-Chlorophenyl)ethyl]piperazin-1-yl]-3-[(4-chlorophenyl)methyl]-1,2,4-thiadiazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 5-[4-[2-(4-Chlorophenyl)ethyl]piperazin-1-yl]-3-[(4-chlorophenyl)methyl]-1,2,4-thiadiazole
• 英文别名: 5-[4-[2-(4-chlorophenyl)ethyl]piperazin-1-yl]-3-[(4-chlorophenyl)methyl]-1,2,4-thiadiazole
• 化学式: C₂₁H₂₂Cl₂N₄S
• 分子量: 433.4
• InChiKey: PEECBJLNAOURNH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  60.5
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• PIPERAZINE THIAZOLE DERIVATIVES USEFUL IN THE TREATMENT OF TAUOPATHIES SUCH AS ALZHEIMER'S DISEASE
  申请人：Griffioen Gerard

  公开号：US20140206699A1

  公开（公告）日：2014-07-24

  The present invention relates to a compound of formula (IA), wherein G 1 is lower alkyl; lower alkyl substituted by one or more halogens; cycloalkyl; tetrahydropyran-4-yl; phenethyl; phenethyl substituted by one or more halogens; phenoxymethyl; phenoxymethyl substituted by one or more halogens; benzyloxyethyl; benzyloxy-ethyl substituted by one or more halogens; or is —NR 2 R 3 ; R 2 is hydrogen or lower alkyl; R 3 is lower alkyl; tetrahydropyran-4-yl; —CH 2 -cycloalkyl; or cycloalkyl optionally substituted by lower alkyl substituted by one or more halogens; or R 2 and R 3 form together with the N-atom to which they are attached a heterocycloalkyl group with 4 or 5 carbon atoms, which is optionally substituted by one or more substituents selected from halogen; or lower alkyl substituted by one or more halogens; X is —CH 2 — or —(CH 2 ) 2 —; Ar is phenyl or pyridinyl; R 4 is halogen; lower alkyl; lower alkyl substituted by one or more halogens; or lower alkoxy; n is 1 or 2; or to a pharmaceutically active salt thereof, to a stereoisomeric form, including an individual diastereoisomer or enantiomer of the compound of formula (IA) as well as to a racemic or non-racemic mixture thereof. The present invention also relates to the use of a compound of formula (IA) for treating certain neurodegenerative disorders characterized by cytotoxic TAU misfolding and/or aggregation.

  本发明涉及式（IA）的化合物，其中G1是低碳基；被一个或多个卤素取代的低碳基；环烷基；四氢吡喃-4-基；苯乙基；被一个或多个卤素取代的苯乙基；苯氧甲基；被一个或多个卤素取代的苯氧甲基；苄氧乙基；被一个或多个卤素取代的苄氧乙基；或为-NR2R3；R2为氢或低碳基；R3为低碳基；四氢吡喃-4-基；-CH2-环烷基；或环烷基，该环烷基可被一个或多个被一个或多个卤素取代的低碳基取代；或R2和R3与它们附着的N原子一起形成一个有4或5个碳原子的杂环烷基，该杂环烷基可被一个或多个取代基选自卤素；或被一个或多个卤素取代的低碳基取代；X为- -或-( )2-；Ar为苯基或吡啶基；R4为卤素；低碳基；被一个或多个卤素取代的低碳基；或低碳氧基；n为1或2；或其药物活性盐，立体异构体形式，包括化合物（IA）的单个对映异构体或对映体以及它们的外消旋或非外消旋混合物。本发明还涉及使用式（IA）的化合物治疗某些神经退行性疾病，其特征为细胞毒性TAU错折和/或聚集。
• US9187440B2
  申请人：——

  公开号：US9187440B2

  公开（公告）日：2015-11-17
• US9808456B2
  申请人：——

  公开号：US9808456B2

  公开（公告）日：2017-11-07