(4-Methyl-5-phenyl-3,4-dihydropyrazol-2-yl)-(4-phenylpiperazin-1-yl)methanethione | 1019283-53-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (4-Methyl-5-phenyl-3,4-dihydropyrazol-2-yl)-(4-phenylpiperazin-1-yl)methanethione
• CAS: 1019283-53-4
• 化学式: C₂₁H₂₄N₄S
• 分子量: 364.514
• InChiKey: LJMOAEOVILJZOK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  54.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-phenylpiperazine-1-carbothiohydrazide 、 2-苯甲酰基丙基二甲基氯化铵 在 sodium hydroxide 作用下， 以 甲醇 为溶剂， 以13%的产率得到(4-Methyl-5-phenyl-3,4-dihydropyrazol-2-yl)-(4-phenylpiperazin-1-yl)methanethione
  参考文献：
  名称：

  Novel Pd(II) complexes of 1-N-substituted 3-phenyl-2-pyrazoline derivatives and evaluation of antiamoebic activity

  摘要：

  Cyclization of Mannich base with N(4)-substituted thiosemicarbazides by different aliphatic, aromatic and cyclic amines afforded a series of new 1-N-substituted cyclised pyrazoline analogues of thiosemicarbazones (PYZ-TSC) 1-10. Reaction of [Pd(DMSO)(2)Cl(2)] with pyrazoline derivatives led to new palladium(II) complexes [Pd(PYZ-TSC)Cl(2)] 1a-10a. The structures of all the compounds were characterized by spectroscopic methods. It was concluded that the pyrazoline thiosemicarbazone derivatives have two chelating arms, one attached at the 2-position of the pyrazole ring (that is, N donor) and other (S donor) linked to the thiosemicarbazone branch. The determination of antiamoebic activity of all the compounds was done using HM1:-IMSS strain of Entamoeba histolytica, among all the complexes, 8a showed the most promising IC(50) = 0.37 mu M vs. IC(50) = 1.81 mu M of metronidazole, the reference drug. MTT assay showed that the compounds are non-toxic to human kidney epithelial cell line. (c) 2007 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2007.03.021

文献信息

• Novel Pd(II) complexes of 1-N-substituted 3-phenyl-2-pyrazoline derivatives and evaluation of antiamoebic activity
  作者：Kakul Husain、Mohammad Abid、Amir Azam

  DOI：10.1016/j.ejmech.2007.03.021

  日期：2008.2

  Cyclization of Mannich base with N(4)-substituted thiosemicarbazides by different aliphatic, aromatic and cyclic amines afforded a series of new 1-N-substituted cyclised pyrazoline analogues of thiosemicarbazones (PYZ-TSC) 1-10. Reaction of [Pd(DMSO)(2)Cl(2)] with pyrazoline derivatives led to new palladium(II) complexes [Pd(PYZ-TSC)Cl(2)] 1a-10a. The structures of all the compounds were characterized by spectroscopic methods. It was concluded that the pyrazoline thiosemicarbazone derivatives have two chelating arms, one attached at the 2-position of the pyrazole ring (that is, N donor) and other (S donor) linked to the thiosemicarbazone branch. The determination of antiamoebic activity of all the compounds was done using HM1:-IMSS strain of Entamoeba histolytica, among all the complexes, 8a showed the most promising IC(50) = 0.37 mu M vs. IC(50) = 1.81 mu M of metronidazole, the reference drug. MTT assay showed that the compounds are non-toxic to human kidney epithelial cell line. (c) 2007 Elsevier Masson SAS. All rights reserved.