4-chloro-N'-(4-phenylpiperazine-1-carbonothionyl)picolinohydrazonamide | 1192456-49-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-chloro-N'-(4-phenylpiperazine-1-carbonothionyl)picolinohydrazonamide
• 英文别名: N-[(E)-[amino-(4-chloropyridin-2-yl)methylidene]amino]-4-phenylpiperazine-1-carbothioamide
• CAS: 1192456-49-7
• 化学式: C₁₇H₁₉ClN₆S
• 分子量: 374.897
• InChiKey: JSBGEAGPFALUQX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  102
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-phenylpiperazine-1-carbothiohydrazide 、 4-氯-2-氰基吡啶 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 甲醇 为溶剂， 反应 5.19h， 以52%的产率得到4-chloro-N'-(4-phenylpiperazine-1-carbonothionyl)picolinohydrazonamide
  参考文献：
  名称：

  The Synthesis and Microbiological Activity of New 4-Chloropyridin-2-yl Derivatives

  摘要：

  4-chloropicolinamide is described. The desired compounds were formed by reactions of methyl 4-chloropicolinohydrazonamide or 4-chloro-N'-methylpicolinohydrazonamide with suitable counter partners (carbon disulfide, alkyl halides, aldehydes, ketones, carbohydrazonamides or isothiocyanates) or via 4-chloropicolinimidate, obtained by a convenient method from nitrile with catalytic amount of DBU. Selected products were screened for bacteriostatic and tuberculostatic activity. Synthesis of 4-chloropicolinamidrazone derivatives starting from

  DOI：

  10.3987/com-09-11696

文献信息

• The Synthesis and Microbiological Activity of New 4-Chloropyridin-2-yl Derivatives
  作者：Agnieszka Bogdanowicz、Henryk Foks、Anna Kędzia、Ewa Kwapisz、Zofia Zwolska、Ewa Augustynowicz-Kopeć

  DOI：10.3987/com-09-11696

  日期：——

  4-chloropicolinamide is described. The desired compounds were formed by reactions of methyl 4-chloropicolinohydrazonamide or 4-chloro-N'-methylpicolinohydrazonamide with suitable counter partners (carbon disulfide, alkyl halides, aldehydes, ketones, carbohydrazonamides or isothiocyanates) or via 4-chloropicolinimidate, obtained by a convenient method from nitrile with catalytic amount of DBU. Selected products were screened for bacteriostatic and tuberculostatic activity. Synthesis of 4-chloropicolinamidrazone derivatives starting from