2-[4-[4-(2-Methoxyphenyl)piperazin-1-yl]butan-2-yl]isoindole-1,3-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-[4-[4-(2-Methoxyphenyl)piperazin-1-yl]butan-2-yl]isoindole-1,3-dione
• 英文别名: 2-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butan-2-yl]isoindole-1,3-dione
• 化学式: C₂₃H₂₇N₃O₃
• 分子量: 393.5
• InChiKey: DCMZWBLLDCYRFE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  53.1
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Deuterium-Enriched Alkyl Sulfonamides and Uses Thereof
  申请人：Dhanoa Daljit Singh

  公开号：US20140221395A1

  公开（公告）日：2014-08-07

  The present invention is concerned with deuterium-enriched sulfonamides of formula 1, their pharmaceutically acceptable salts and methods of use thereof for the treatment of anxiety disorders including, General Anxiety Disorder (GAD), Panic Disorder (PD), Post-Traumatic Stress Disorder (PTSD), Social Phobia (SP), Health Anxiety (Hypochondriasis), depression, major depressive disorders, unipolar depression, bipolar I depression disorder, bipolar II depression disorder, treatment-resistant depression, single episodic and recurrent major depressive disorders, depression in the medically ill, attention deficit hyperactivity disorder (ADHD), attention deficit disorder (ADD), Obsessive-Compulsive Disorder (OCD), Obsessive-Compulsive Personality Disorder (OCPD), Autism Spectrum Disorder (ASD), schizophrenia, psychosis, epilepsy, seizures, hot flashes due to menopause, age-related macular degeneration (AMD), premature ejaculation, male erectile dysfunction, sexual dysfunction, obesity, eating disorders, bulimia nervosa, anorexia nervosa, angina, migraine, pain, nociception, sleep disorders, insomnia, fibromyalgia, alcohol withdrawal, autism, Rett's syndrome, cyclothymic disorder, neural injury, neurodegenerative diseases, Parkinson's disease, Parkinson's disease psychosis, Huntington disease, Alzheimer's disease, frontotemporal dementia, cognitive impairment associated with age-related dementia, Alzheimer's disease, schizophrenia, psychosis, depression, pain or discomfort associated with surgery and pain or discomfort associated with medical illness.
• US8927553B2
  申请人：——

  公开号：US8927553B2

  公开（公告）日：2015-01-06