[(2R,3S,4R,5R)-3,4-dihydroxy-5-(2-methyl-6-oxo-1H-purin-9-yl)oxolan-2-yl]methyl dihydrogen phosphate

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 英文名称: [(2R,3S,4R,5R)-3,4-dihydroxy-5-(2-methyl-6-oxo-1H-purin-9-yl)oxolan-2-yl]methyl dihydrogen phosphate
• 化学式: C₁₁H₁₅N₄O₈P
• 分子量: 362.23
• InChiKey: UAXHXNQMDHWKEZ-IOSLPCCCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.8
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  176
• 氢给体数：
  5
• 氢受体数：
  9

文献信息

• MODIFIED POLYNUCLEOTIDES FOR TREATING GALACTOSYLCERAMIDASE PROTEIN DEFICIENCY
  申请人：Moderna Therapeutics, Inc.

  公开号：US20140221465A1

  公开（公告）日：2014-08-07

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
• IN VIVO PRODUCTION OF PROTEINS
  申请人：Moderna Therapeutics, Inc.

  公开号：US20150111248A1

  公开（公告）日：2015-04-23

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
• MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF
  申请人：Moderna Therapeutics, Inc.

  公开号：US20160354492A1

  公开（公告）日：2016-12-08

  The present disclosure provides modified nucleosides, nucleotides, and nucleic acids, and methods of using them.
• US9221891B2
  申请人：——

  公开号：US9221891B2

  公开（公告）日：2015-12-29