2-Methoxyethyl 4-tert-butylpiperazine-1-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-Methoxyethyl 4-tert-butylpiperazine-1-carboxylate
• 英文别名: 2-methoxyethyl 4-tert-butylpiperazine-1-carboxylate
• 化学式: C₁₂H₂₄N₂O₃
• 分子量: 244.33
• InChiKey: WJSCLJBOILVBJY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  42
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• REGULATION OF NITRIC OXIDE RELEASE AND BIOFILM DEVELOPMENT
  申请人：UNIVERSITY OF WOLLONGONG

  公开号：US20140221331A1

  公开（公告）日：2014-08-07

  The present invention relates generally to methods and compounds for regulating the release of nitric oxide in the vicinity of biofilm-forming microorganisms to regulate programmed cell death in the microorganisms and thereby promote dispersal of microorganism from biofilms and/or inhibit biofilm formation or development. More particularly, the invention relates to the use of compounds to provide spatial and temporal control over nitric oxide release.
• CARM1 INHIBITORS AND USES THEREOF
  申请人：Epizyme, Inc.

  公开号：US20170305922A1

  公开（公告）日：2017-10-26

  Provided herein are compounds of Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, wherein R1, R2a, R2b, R3 and Ring B are as defined herein, and Ring A is a group of Formula (A-i), (A-ii), or (A-iii): wherein R, R, R, R, and R are as defined herein. Compounds of the present invention are useful for inhibiting CARM1 activity. Methods of using the compounds for treating CARM1-mediated disorders are also described.
• US9156855B2
  申请人：——

  公开号：US9156855B2

  公开（公告）日：2015-10-13