Amino 4-methylpiperazine-1-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: Amino 4-methylpiperazine-1-carboxylate
• 英文别名: amino 4-methylpiperazine-1-carboxylate
• 化学式: C₆H₁₃N₃O₂
• 分子量: 159.19
• InChiKey: ABORYXKMBJZRJJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  58.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] AZETIDOBENZODIAZEPINE DIMERS AND CONJUGATES COMPRISING THEM FOR USE IN THE TREATMENT OF CANCER<br/>[FR] DIMÈRES D'AZÉTIDOBENZODIAZÉPINE ET CONJUGUÉS LES COMPRENANT DESTINÉS À ÊTRE UTILISÉS DANS LE TRAITEMENT DU CANCER
  申请人：MEDIMMUNE LTD

  公开号：WO2020187721A1

  公开（公告）日：2020-09-24

  A compound of formula IV: as well as drug-linkers and conjugates comprising this compound, and the use of the conjugates in treating cancer.

  公式IV的化合物，以及包含该化合物的药物连接剂和共轭物，以及利用这些共轭物治疗癌症。
• REGULATION OF NITRIC OXIDE RELEASE AND BIOFILM DEVELOPMENT
  申请人：UNIVERSITY OF WOLLONGONG

  公开号：US20140221331A1

  公开（公告）日：2014-08-07

  The present invention relates generally to methods and compounds for regulating the release of nitric oxide in the vicinity of biofilm-forming microorganisms to regulate programmed cell death in the microorganisms and thereby promote dispersal of microorganism from biofilms and/or inhibit biofilm formation or development. More particularly, the invention relates to the use of compounds to provide spatial and temporal control over nitric oxide release.
• PYRAZOLO[1,5-A]PYRIMIDINES FOR ANTIVIRAL TREATMENT
  申请人：Gilead Sciences, Inc.

  公开号：US20170190708A1

  公开（公告）日：2017-07-06

  The invention provides compounds of Formula I or Formula II: or a pharmaceutically acceptable salt or ester, thereof, as described herein. The compounds and compositions thereof are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.
• US9156855B2
  申请人：——

  公开号：US9156855B2

  公开（公告）日：2015-10-13
• [EN] GLYCOCONJUGATES<br/>[FR] GLYCOCONJUGUÉS
  申请人：[en]ADC THERAPEUTICS SA

  公开号：WO2022079211A1

  公开（公告）日：2022-04-21

  This disclosure relates to glycoconjugates comprising glycosylated cell-binding agents conjugated to pyrrolobenzodiazepine (PBD) payloads. Glycoconjugates of particular interest include conjugates where the cell-binding agent is an antibody and the payload comprises a cytotoxic pyrrolobenzodiazepine (PBD) moiety, with the PBD moiety conjugated to the antibody via an oligosaccharide linker. The disclosure also relates to methods for preparing the glycoconjugates, along with methods for their use.