3-[4-[4-(2-acetyl-1-benzofuran-5-yl)piperazin-1-yl]butyl]-1H-indene-5-carbonitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 3-[4-[4-(2-acetyl-1-benzofuran-5-yl)piperazin-1-yl]butyl]-1H-indene-5-carbonitrile
• 化学式: C₂₈H₂₉N₃O₂
• 分子量: 439.5
• InChiKey: VXJOOOXOODOLIX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  33
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  60.5
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• 5-HTP COMBINATION THERAPY
  申请人：Sanchez Morillo Connie

  公开号：US20120258984A1

  公开（公告）日：2012-10-11

  The present invention relates to combination therapies and pharmaceutical compositions comprising a combination of 5-hydroxytryptophan and a serotonin reuptake inhibitor. The present invention provides a pharmaceutical composition comprising (i) a serotonin reuptake inhibitor and (ii) 5-hydroxytrytophan. The present invention further provides a pharmaceutical composition comprising (i) 5-hydroxytryptophan in an amount ranging from about 1 mg to about 75 mg; and (ii) a serotonin reuptake inhibitor. The present invention also provides a pharmaceutical composition comprising (i) a subclinical dose of a serotonin reuptake inhibitor; and (ii) 5-hydroxytryptophan.
• US8802851B2
  申请人：——

  公开号：US8802851B2

  公开（公告）日：2014-08-12