[6-[6-[[(2S,3R,5S)-5-(2-amino-6-oxo-1H-purin-9-yl)-3-[2-[(2R,3R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-2-[[hydroxy-[6-(1-methyl-2,5-dioxopyrrolidin-3-yl)sulfanylhexoxy]phosphoryl]oxymethyl]oxolan-3-yl]oxyethoxy]oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyhexylcarbamoyl]-6'-(2,2-dimethylpropanoyloxy)-3-oxospiro[2-benzofuran-1,9'-xanthene]-3'-yl] 2,2-dimethylpropanoate

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 英文名称: [6-[6-[[(2S,3R,5S)-5-(2-amino-6-oxo-1H-purin-9-yl)-3-[2-[(2R,3R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-2-[[hydroxy-[6-(1-methyl-2,5-dioxopyrrolidin-3-yl)sulfanylhexoxy]phosphoryl]oxymethyl]oxolan-3-yl]oxyethoxy]oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyhexylcarbamoyl]-6'-(2,2-dimethylpropanoyloxy)-3-oxospiro[2-benzofuran-1,9'-xanthene]-3'-yl] 2,2-dimethylpropanoate
• 化学式: C₆₉H₈₆N₁₀O₂₄P₂S
• 分子量: 1533.5
• InChiKey: BQWOJAYMEPEFJT-BWMCYUANSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  106
• 可旋转键数：
  37
• 环数：
  11.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  472
• 氢给体数：
  6
• 氢受体数：
  26

文献信息

• REMOTE ASSEMBLY OF TARGETED NANOPARTICLES USING COMPLEMENTARY OLIGONUCLEOTIDE LINKERS
  申请人：Mallinckrodt LLC

  公开号：US20140234217A1

  公开（公告）日：2014-08-21

  The present invention provides targeted delivery compositions and their methods of use in treating and diagnosing a disease state in a subject. Components of the targeted delivery compositions are put together through duplex formation between oligonucleotides.