N-Cyclohexyl-N'-(2-methylcyclohexyl)urea | 17661-70-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 英文名称: N-Cyclohexyl-N'-(2-methylcyclohexyl)urea
• 英文别名: 1-cyclohexyl-3-(2-methylcyclohexyl)urea
• CAS: 17661-70-0
• 化学式: C₁₄H₂₆N₂O
• mdl: MFCD03414465
• 分子量: 238.373
• InChiKey: ANYYUZRBKJKUKO-UHFFFAOYSA-N

物化性质

• 熔点：
  227 °C(Solv: methanol (67-56-1))
• 沸点：
  412.1±12.0 °C(Predicted)
• 密度：
  1.00±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.928
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  cyclo-hexyl carbamate 4-nitrophenyl ester 、 2-甲基环己胺 以 二氯甲烷 为溶剂， 反应 4.0h， 以57%的产率得到N-Cyclohexyl-N'-(2-methylcyclohexyl)urea
  参考文献：
  名称：

  Izdebski, Jan; Pawlak, Danuta, Synthesis, 1989, # 6, p. 423 - 425

  摘要：

  DOI：

文献信息

• INHIBITORS OF EPOXIDE HYDROLASES FOR THE TREATMENT OF INFLAMMATION
  申请人：Hammock D. Bruce

  公开号：US20070117782A1

  公开（公告）日：2007-05-24

  The invention provides compounds that inhibit epoxide hydrolase in therapeutic applications for treating hypertension. A preferred class of compounds for practicing the invention have the structure shown by Formula 1 wherein Z is oxygen or sulfur, W is carbon phosphorous or sulfur, X and Y is each independently nitrogen, oxygen, or sulfur, and X can further be carbon, at least one of R 1 -R 4 is hydrogen, R 2 is hydrogen when X is nitrogen but is not present when X is sulfur or oxygen, R 4 is hydrogen when Y is nitrogen but is not present when Y is sulfur or oxygen, R 1 and R 3 is each independently C 1 -C 20 substituted or unsubstituted alkyl, cycloalkyl, aryl, acyl, or heterocyclic.

  本发明提供了一些化合物，用于治疗高血压的治疗应用中，抑制环氧水解酶。实施本发明的优选化合物类别具有由式1所示的结构，其中Z为氧或硫，W为碳、磷或硫，X和Y各自独立地为氮、氧或硫，而X还可以是碳，R1-R4中至少有一个是氢，当X为氮时，R2为氢，但当X为硫或氧时，R2不存在，当Y为氮时，R4为氢，但当Y为硫或氧时，R4不存在，而R1和R3各自独立地为C1-C20取代或未取代的烷基、环烷基、芳基、酰基或杂环基。
• IZDEBSKI, JAN;PAWLAK, DANUTA, SYNTHESIS (BRD),(1989) N, C. 423-425
  作者：IZDEBSKI, JAN、PAWLAK, DANUTA

  DOI：——

  日期：——
• INHIBITORS OF EPOXIDE HYDROLASES FOR THE TREATMENT OF HYPERTENSION
  申请人：Kroetz Deanna L.

  公开号：US20110245331A1

  公开（公告）日：2011-10-06

  The invention provides compounds that inhibit epoxide hydrolase in therapeutic applications for treating hypertension. A preferred class of compounds for practicing the invention have the structure shown by Formula 1 wherein Z is oxygen or sulfur, W is carbon phosphorous or sulfur, X and Y is each independently nitrogen, oxygen, or sulfur, and X can further be carbon, at least one of R 1 -R 4 is hydrogen, R 2 is hydrogen when X is nitrogen but is not present when X is sulfur or oxygen, R 4 is hydrogen when Y is nitrogen but is not present when Y is sulfur or oxygen, R 1 and R 3 is each independently C 1 -C 20 substituted or unsubstituted alkyl, cycloalkyl, aryl, acyl, or heterocyclic.
• US8815951B2
  申请人：——

  公开号：US8815951B2

  公开（公告）日：2014-08-26
• Izdebski, Jan; Pawlak, Danuta, Synthesis, 1989, # 6, p. 423 - 425
  作者：Izdebski, Jan、Pawlak, Danuta

  DOI：——

  日期：——