8-[7-(3,5-dimethyl-1,2-oxazol-4-yl)-6-methoxy-2-methyl-9H-pyrimido[4,5-b]indol-4-yl]-3,4-dihydro-2H-pyrano[3,2-b]pyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃吡啶类
• 英文名称: 8-[7-(3,5-dimethyl-1,2-oxazol-4-yl)-6-methoxy-2-methyl-9H-pyrimido[4,5-b]indol-4-yl]-3,4-dihydro-2H-pyrano[3,2-b]pyridine
• 化学式: C₂₅H₂₃N₅O₃
• 分子量: 441.5
• InChiKey: HQHYFGUPVRCQEM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  33
• 可旋转键数：
  3
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  99
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• BET bromodomain inhibitors and therapeutic methods using the same
  申请人：THE REGENTS OF THE UNIVERSITY OF MICHIGAN

  公开号：US10391175B2

  公开（公告）日：2019-08-27

  Inhibitors of BET bromodomains and compositions containing the same are disclosed. Methods of using the BET bromodomain inhibitors in the treatment of diseases and conditions wherein inhibition of BET bromodomain provides a benefit, like cancers, also are disclosed.

  本研究公开了 BET 溴基链抑制剂和含有这些抑制剂的组合物。此外，还公开了将 BET 溴基链抑制剂用于治疗 BET 溴基链抑制可带来益处的疾病和病症（如癌症）的方法。
• US20140256706A1
  申请人：——

  公开号：US20140256706A1

  公开（公告）日：2014-09-11
• BET BROMODOMAIN INHIBITORS AND THERAPEUTIC METHODS USING THE SAME
  申请人：THE REGENTS OF THE UNIVERSITY OF MICHIGAN

  公开号：US20170281773A1

  公开（公告）日：2017-10-05

  Inhibitors of BET bromodomains and compositions containing the same are disclosed. Methods of using the BET bromodomain inhibitors in the treatment of diseases and conditions wherein inhibition of BET bromodomain provides a benefit, like cancers, also are disclosed.
• US9675697B2
  申请人：——

  公开号：US9675697B2

  公开（公告）日：2017-06-13