3-(4-Hydroxyphenyl)piperazine-1-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 3-(4-Hydroxyphenyl)piperazine-1-carboxylic acid
• 英文别名: 3-(4-hydroxyphenyl)piperazine-1-carboxylic acid
• 化学式: C₁₁H₁₄N₂O₃
• 分子量: 222.24
• InChiKey: RKWGLIQNMVSWOU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  72.8
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Azaindole derivatives as Rho-kinase inhibitors
  申请人：CHIESI FARMACEUTICI S.p.A.

  公开号：US11332468B2

  公开（公告）日：2022-05-17

  The invention relates to compounds of formula I inhibiting Rho Kinase that are tyrosine analogues derivatives, processes of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).

  本发明涉及抑制 Rho 激酶的酪氨酸类似物衍生物的式 I 化合物、制备此类化合物的工艺、含有此类化合物的药物组合物及其治疗用途。特别是本发明的化合物可用于治疗许多与 ROCK 酶机制相关的疾病，如肺部疾病，包括哮喘、慢性阻塞性肺病 (COPD)、特发性肺纤维化 (IPF) 和肺动脉高压 (PAH)。
• AZAINDOLE DERIVATIVES AS RHO-KINASE INHIBITORS
  申请人：Chiesi Farmaceutici S.p.A.

  公开号：EP3728248B1

  公开（公告）日：2022-02-02
• US20140273458A1
  申请人：——

  公开号：US20140273458A1

  公开（公告）日：2014-09-18
• AZAINDOLE DERIVATIVES AS RHO- KINASE INHIBITORS
  申请人：CHIESI FARMACEUTICI S.p.A.

  公开号：US20200392133A1

  公开（公告）日：2020-12-17

  The invention relates to compounds of formula I inhibiting Rho Kinase that are tyrosine analogues derivatives, processes of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).