5-[5-[4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]-2-methylphenoxy]-1H-pyrrolo[2,3-b]pyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 5-[5-[4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohexen-1-yl]methyl]piperazin-1-yl]-2-methylphenoxy]-1H-pyrrolo[2,3-b]pyridine
• 化学式: C₃₃H₃₇ClN₄O
• 分子量: 541.1
• InChiKey: KXGDCYFPPCTERV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  39
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  44.4
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• PROCESSES FOR THE PREPARATION OF AN APOPTOSIS-INDUCING AGENT
  申请人：AbbVie Inc.

  公开号：EP3293185A1

  公开（公告）日：2018-03-14

  Provided herein is a process for the preparation of an apoptosis-inducing agent, and chemical intermediates thereof. Also provided herein are novel chemical intermediates related to the process provided herein.

  本文提供了一种制备诱导细胞凋亡剂及其化学中间体的方法。此外，本文还提供了与所提供的方法相关的新型化学中间体。
• PROCESS FOR PREPARING A SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF AN APOPTOSIS-INDUCING AGENT
  申请人：AbbVie Inc.

  公开号：EP3569588A1

  公开（公告）日：2019-11-20

  Provided herein is a process for the preparation of an apoptosis-inducing agent, and chemical intermediates thereof. Also provided herein are novel chemical intermediates related to the process provided herein.

  本文提供了一种凋亡诱导剂的制备工艺及其化学中间体。本文还提供了与本文所提供工艺相关的新型化学中间体。
• PROCESSES AND INTERMEDIATES USEFUL IN THE PREPARATION OF AN APOPTOSIS-INDUCING AGENT
  申请人：AbbVie Ireland Unlimited Company

  公开号：EP3954687A1

  公开（公告）日：2022-02-16

  Provided herein is a process for the preparation of an apoptosis-inducing agent, and chemical intermediates thereof. Also provided herein are novel chemical intermediates related to the process provided herein.

  本文提供了一种凋亡诱导剂的制备工艺及其化学中间体。本文还提供了与本文所提供工艺相关的新型化学中间体。
• US20140275540A1
  申请人：——

  公开号：US20140275540A1

  公开（公告）日：2014-09-18
• PROCESS FOR THE PREPARATION OF VENETOCLAX
  申请人：MYLAN LABORATORIES LIMITED

  公开号：US20190177317A1

  公开（公告）日：2019-06-13

  The present disclosure provides novel synthetic process for the preparation of venetoclax. The disclosed processes involve the use of novel intermediates. Processes for the preparation of these intermediates are also disclosed as well as methods for the preparation of particularly useful salts thereof.