2-(1-Cyclopropyl-6-fluoro-4-methylidene-7-piperazin-1-ylquinolin-3-yl)prop-2-enoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-(1-Cyclopropyl-6-fluoro-4-methylidene-7-piperazin-1-ylquinolin-3-yl)prop-2-enoic acid
• 英文别名: 2-(1-cyclopropyl-6-fluoro-4-methylidene-7-piperazin-1-ylquinolin-3-yl)prop-2-enoic acid
• 化学式: C₂₀H₂₂FN₃O₂
• 分子量: 355.4
• InChiKey: FLWWHEXQZRMLBS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  55.8
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• [EN] COMPOUNDS AND COMPOSITIONS FOR DRUG RELEASE<br/>[FR] COMPOSÉS ET COMPOSITIONS POUR LIBÉRATION DE MÉDICAMENT
  申请人：INTERFACE BIOLOGICS INC

  公开号：WO2014139033A1

  公开（公告）日：2014-09-18

  The invention relates to compounds that include biologically active agents (e.g., compounds according to any of formulas (I) and (I-A) that can be used for effective drug release, e.g., as coatings for medical devices. Use of these compounds in the coating of surfaces can allow for long-term drug release as well as imparting uniform coatings with little phase separation compared to, e.g., the parent biologically active agent.