The invention relates to a process for the preparation of tetrasubstituted ureas by reaction of the corresponding amines with phosgene in the presence of an aqueous inorganic base at a temperature in the range from 0 to 150° C., which comprises: feeding the corresponding amine, the phosgene and the aqueous inorganic base on average continuously to the reaction apparatus, forming a two-phase system in the reaction apparatus through the choice of the tetrasubstituted ureas to be prepared, through the mixing ratios of the substances and substance mixtures to be fed in, through the temperature during the reaction and, where appropriate, through the feed of an organic solvent which is not completely miscible with water, and discharging the reaction mixture on average continuously from the reaction apparatus.
本发明涉及一种制备四取代
脲的工艺,该工艺是在无机
水基存在下,在 0 至 150 摄氏度的温度范围内,通过相应的胺与
光气反应制备四取代
脲、其中包括:将相应的胺、
光气和
水性
无机碱平均连续地加入反应装置中,通过选择要制备的四代
脲,通过加入的物质和物质混合物的混合比,通过反应过程中的温度,并酌情通过加入与
水不完全混溶的有机溶剂,在反应装置中形成两相体系,并将反应混合物平均连续地从反应装置中排出。