(Z)-2-(2,6-dichlorophenyl)-3-(5-(6-(piperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)acrylonitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (Z)-2-(2,6-dichlorophenyl)-3-(5-(6-(piperazin-1-yl)pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)acrylonitrile
• 英文别名: (Z)-2-(2,6-dichlorophenyl)-3-(5-(6-(piperazine-1-yl)pyridine-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-yl)acrylonitrile；(Z)-2-(2,6-dichlorophenyl)-3-[5-(6-piperazin-1-ylpyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]prop-2-enenitrile
• 化学式: C₂₅H₂₀Cl₂N₆
• 分子量: 475.38
• InChiKey: JJSUQKQZBGEOQO-LICLKQGHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  33
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  80.6
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] ALKENYL COMPOUNDS AND METHODS OF USE<br/>[FR] COMPOSÉS ALCÉNYLES ET PROCÉDÉS D'UTILISATION
  申请人：CALITOR SCIENCES LLC

  公开号：WO2014193647A2

  公开（公告）日：2014-12-04

  The present invention provides novel substituted alkenyl compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating cellular activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.