hydron;8-methyl-3-(4-methylpiperazin-1-yl)-1H-quinolin-2-one;chloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: hydron;8-methyl-3-(4-methylpiperazin-1-yl)-1H-quinolin-2-one;chloride
• 化学式: C15H20ClN3O
• 分子量: 293.79
• InChiKey: CDUMSUZZXUTHFJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.01
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  35.6
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP0236140A2

  公开（公告）日：1987-09-09

  Carbostyril derivatives or salt thereof, including novel compounds, having activities for curing and/or improving arrhythmia. Some carbostyril devitavies having similar chemical structural formula to those of carbostyril derivatives of the present invention are known in the prior art references, however, above-mentioned parmacological activities have not been known yet.

  具有治疗和/或改善心律失常活性的羧基吡啶衍生物或其盐，包括新型化合物。 一些与本发明羧基吡啶衍生物具有相似化学结构式的羧基吡啶衍生物在现有技术参考文献中是已知的，但是，上述心律失常活性尚未为人所知。
• Compositions of a cyclooxygenase-2 selective inhibitor and a potassium ion channel modulator for the treatment of central nervous system damage
  申请人：Stephenson T. Diane

  公开号：US20050009733A1

  公开（公告）日：2005-01-13

  The present invention provides compositions and methods for the treatment of central nervous system damage in a subject. More particularly, the invention provides a combination therapy for the treatment of a central nervous system ischemic condition or a central nervous system traumatic injury comprising the administration to a subject of a potassium ion channel modulator in combination with a cyclooxygenase-2 selective inhibitor.

  本发明提供了治疗受试者中枢神经系统损伤的组合物和方法。更具体地说，本发明提供了一种用于治疗中枢神经系统缺血性疾病或中枢神经系统创伤性损伤的组合疗法，包括向受试者施用钾离子通道调节剂与环氧合酶-2 选择性抑制剂。