6,6’-双鹅掌菜酚 | 88095-81-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 单宁
• 中文名称: 6,6’-双鹅掌菜酚
• 中文别名: 6,6'-双鹅掌菜酚
• 英文名称: 6,6'-bieckol
• 英文别名: 4-(3,5-dihydroxyphenoxy)-9-[6-(3,5-dihydroxyphenoxy)-2,4,7,9-tetrahydroxydibenzo-p-dioxin-1-yl]dibenzo-p-dioxin-1,3,6,8-tetrol
• CAS: 88095-81-2
• 化学式: C₃₆H₂₂O₁₈
• 分子量: 742.56
• InChiKey: HBJNTPFHQKXWOY-UHFFFAOYSA-N

物化性质

• 熔点：
  >300 °C
• 沸点：
  1089.5±65.0 °C(Predicted)
• 密度：
  1.882±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  54
• 可旋转键数：
  5
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  298
• 氢给体数：
  12
• 氢受体数：
  18

反应信息

• 作为反应物：
  描述：

  6,6’-双鹅掌菜酚 生成 9,9'-bieckol dodeca-acetate
  参考文献：
  名称：

  FUKUYAMA, JOSIYASU;KANASIRO, JORIXIDEH;MIURA, IVAO;NAKAYAMA, YASUO;TAKAXA+

  摘要：

  DOI：

文献信息

• ECKOL DERIVATIVES, METHODS OF SYNTHESIS AND USES THEREOF
  申请人：Phloronol, Inc.

  公开号：US20180127392A1

  公开（公告）日：2018-05-10

  Provided herein are eckol derivatives, methods of synthesis thereof and pharmaceutical compositions thereof. In other embodiments, provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders such as, for example, Alzheimer's disease, microbial infections, obesity, diabetes, cancer or inflammation using the compounds and pharmaceutical compositions disclosed herein.

  本文提供了eckol衍生物、其合成方法和药物组成物。在其他实施例中，提供了使用本文中披露的化合物和药物组成物治疗、预防或缓解多种医学疾病的方法，例如阿尔茨海默病、微生物感染、肥胖症、糖尿病、癌症或炎症。
• Solid pharmaceutical compositions of brown algae
  申请人：PHLORONOL, INC.

  公开号：US10016471B2

  公开（公告）日：2018-07-10

  Described herein are solid pharmaceutical compositions of brown algae extracts and methods for making solid pharmaceutical compositions of brown algae extracts. In some embodiments, the brown algae extract is derived from Ecklonia cava.

  本文描述了褐藻提取物的固体药物组合物和褐藻提取物固体药物组合物的制造方法。在某些实施方案中，褐藻提取物来自Ecklonia cava。
• Composition for preventing or treating stenosis including brown algae extract
  申请人：PUKYONG NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION

  公开号：US10905655B2

  公开（公告）日：2021-02-02

  The present invention relates to a composition for preventing or treating stenosis, in which the composition includes brown algae extract, and more particularly to a composition for preventing or treating stenosis, in which the composition includes brown algae-derived polyphenol as an active ingredient, thereby providing excellent prevention or treatment effect on stenosis including tracheal stenosis, glottic stenosis, vascular stenosis, and the like.

  本发明涉及一种用于预防或治疗狭窄的组合物，其中该组合物包括褐藻提取物，更具体地说，涉及一种用于预防或治疗狭窄的组合物，其中该组合物包括作为活性成分的褐藻衍生多酚，从而对包括气管狭窄、声门狭窄、血管狭窄等在内的狭窄具有良好的预防或治疗效果。
• FUKUYAMA, YOSHIYASU;KODAMA, MITSUAKI;MIURA, IWAO;KINZYO, ZIUNEI;MORI, HID+, CHEM. AND PHARM. BULL., 37,(1989) N, C. 2438-2440
  作者：FUKUYAMA, YOSHIYASU、KODAMA, MITSUAKI、MIURA, IWAO、KINZYO, ZIUNEI、MORI, HID+

  DOI：——

  日期：——
• Anti-plasmin inhibitor. V. Structures of novel dimeric eckols isolated from the brown alga Ecklonia kurome Okamura.
  作者：Yoshiyasu FUKUYAMA、Mitsuaki KODAMA、Iwao MIURA、Ziunei KINZYO、Hideo MORI、Yasuo NAKAYAMA、Masayuki TAKAHASHI

  DOI：10.1248/cpb.37.2438

  日期：——

  6, 6'-Bieckol (1), 2-O-(2, 4, 6-trihydroxyphenyl)-6, 6'-bieckol (4), and 8, 8'-bieckol (2), bispolyphenols with a dibenzo-1, 4-dioxin skeleton, have been isolated as potent anti-plasmin inhibitors from the brown alga Ecklonia kurome OKAMURA. Their structures have been determined to be dimers of eckol linked at the C-6 or C-8 positions, through an aryl-aryl bond on the basis of spectral data. Their inhibitory actions on anti-plasmins (α2-macroglobulin and α2-plasmin inhibitor) and some proteases have been examined.