3-[5-[3-(4-Pyridin-4-ylpiperazin-1-yl)pyridin-2-yl]indol-1-yl]propanenitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 3-[5-[3-(4-Pyridin-4-ylpiperazin-1-yl)pyridin-2-yl]indol-1-yl]propanenitrile
• 英文别名: 3-[5-[3-(4-pyridin-4-ylpiperazin-1-yl)pyridin-2-yl]indol-1-yl]propanenitrile
• 化学式: C₂₅H₂₄N₆
• 分子量: 408.506
• InChiKey: IWCGKBDFGQZHIG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  61
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• SUBSTITUTED PYRIDINE-PIPERAZINYL ANALOGUES AS RSV ANTIVIRAL COMPOUNDS
  申请人：JANSSEN SCIENCES IRELAND UC

  公开号：US20160168124A1

  公开（公告）日：2016-06-16

  The invention concerns novel substituted pyridine-piperazinyl analogues of formula (I) having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (RSV). The invention further concerns the preparation of such novel compounds, compositions comprising these compounds, and the compounds for use in the treatment of respiratory syncytial virus infection.