4-(5-Cyanopyridin-2-yl)piperazine-1-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-(5-Cyanopyridin-2-yl)piperazine-1-carboxylic acid
• 英文别名: 4-(5-cyanopyridin-2-yl)piperazine-1-carboxylic acid
• 化学式: C₁₁H₁₂N₄O₂
• 分子量: 232.24
• InChiKey: JVUMGJRWZADHSA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  80.5
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Pyridazinones as PARP7 inhibitors
  申请人：Ribon Therapeutics Inc.

  公开号：US10870641B2

  公开（公告）日：2020-12-22

  The present invention relates to pyridazinones and related compounds which are inhibitors of PARP7 and are useful in the treatment of cancer.

  本发明涉及哒嗪酮类及相关化合物，它们是 PARP7 的抑制剂，可用于治疗癌症。
• SMALL MOLECULE MODULATORS OF PANTOTHENATE KINASES
  申请人：St. Jude Children's Research Hospital, Inc.

  公开号：EP3474667A1

  公开（公告）日：2019-05-01
• POLY-ADP RIBOSE POLYMERASE (PARP) INHIBITORS
  申请人：Mitobridge, Inc.

  公开号：EP3562822A1

  公开（公告）日：2019-11-06
• PYRIDAZINONES AS PARP7 INHIBITORS
  申请人：Ribon Therapeutics Inc.

  公开号：US20200123134A1

  公开（公告）日：2020-04-23

  The present invention relates to pyridazinones and related compounds which are inhibitors of PARP7 and are useful in the treatment of cancer.
• [EN] SMALL MOLECULE MODULATORS OF PANTOTHENATE KINASES<br/>[FR] MODULATEURS À PETITES MOLÉCULES DES PANTOTHÉNATE KINASES
  申请人：ST JUDE CHILDREN'S RES HOSPITAL

  公开号：WO2017223474A1

  公开（公告）日：2017-12-28

  The present disclosure relates to chemical compounds that modulate pantothenate kinase (PanK) activity for the treatment of metabolic disorders (such as diabetes mellitus type II), neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.