[(2R,3S,4R,5R)-5-(2-amino-8-azido-6-oxo-1H-purin-9-yl)-4-hydroxy-2-(phosphonooxymethyl)oxolan-3-yl] dihydrogen phosphate

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 英文名称: [(2R,3S,4R,5R)-5-(2-amino-8-azido-6-oxo-1H-purin-9-yl)-4-hydroxy-2-(phosphonooxymethyl)oxolan-3-yl] dihydrogen phosphate
• 化学式: C10H14N8O11P2
• 分子量: 484.21
• InChiKey: UNGRPPJFCIRKFV-UMMCILCDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.2
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  263
• 氢给体数：
  7
• 氢受体数：
  14

文献信息

• Immunoglobulin having particular framework scaffold and methods of making and using
  申请人：Zhang Mei-Yun

  公开号：US20050037420A1

  公开（公告）日：2005-02-17

  This invention relates to immunoglobulin molecules comprising light chain (V L ) chimeric variable domains, heavy chain (V H ) chimeric variable domains, e.g., scFv antibodies that are expressed at high levels within a host cell, preferably within particular cellular compartments such as, e.g., cytosol or apoplast. The V L , V H and scFv antibody molecules comprise framework scaffolds of particularly preferred framework regions. This invention also relates to nucleic acid molecules encoding the immunoglobulin molecules of this invention, vectors expressing the immunoglobulin molecules, hosts transformed with the nucleic acid molecules and vectors, and methods of using the immunoglobulin molecules. Also described are immunoglobulin libraries as well as host cells, including transgenic plants, expressing the V L , V H or scFv antibody molecules of this invention.

  本发明涉及由轻链（V L ）嵌合可变结构域、重链（V H )嵌合可变结构域的免疫球蛋白分子，例如在宿主细胞内高水平表达的 scFv 抗体，最好是在特定的细胞区，如细胞质或细胞外质中表达。V L , V H 和 scFv 抗体分子包括特别优选框架区域的框架支架。本发明还涉及编码本发明免疫球蛋白分子的核酸分子、表达免疫球蛋白分子的载体、用核酸分子和载体转化的宿主以及使用免疫球蛋白分子的方法。此外，还描述了免疫球蛋白文库以及宿主细胞（包括转基因植物）表达 V L , V H 或 scFv 抗体分子。
• IMMUNOGLOBULIN HAVING PARTICULAR FRAMEWORK SCAFFOLD AND METHODS OF MAKING AND USING
  申请人：FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DERANGEWANDTEN FORSCHUNG E.V.

  公开号：EP1434800A2

  公开（公告）日：2004-07-07
• EP1434800A4
  申请人：——

  公开号：EP1434800A4

  公开（公告）日：2006-05-10
• [EN] IMMUNOGLOBULIN HAVING PARTICULAR FRAMEWORK SCAFFOLD AND METHODS OF MAKING AND USING<br/>[FR] IMMUNOGLOBULINE DOTEE D'UN SQUELETTE PARTICULIER ; METHODES DE FABRICATION ET D'UTILISATION
  申请人：FRAUNHOFER INST MOLEKULARBIOLO

  公开号：WO2003025124A2

  公开（公告）日：2003-03-27

  This invention relates to immunoglobulin molecules comprising light chain (VL) chimeric variable domains, heavy chain (VH) chimeric variable domains, e.g., scFv antibodies that are expressed at high levels within a host cell, preferably within particular cellular compartments such as, e.g., cytosol or apoplast. The VL, VH and scFv antibody molecules comprise framework scaffolds of particularly preferred framework regions. This invention also relates to nucleic acid molecules encoding the immunoglobulin molecules of this invention, vectors expressing the immunoglobulin molecules, hosts transformed with the nucleic acid molecules and vectors, and methods of using the immunoglobulin molecules. Also described are immunoglobulin libraries as well as host cells, including transgenic plants, expressing the VL, VH or scFv antibody molecules of this invention.