6-(哌啶-1-基)己烷-3-醇 | 114105-72-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 6-(哌啶-1-基)己烷-3-醇
• 英文名称: 6-(piperidin-1-yl)hexan-3-ol
• 英文别名: N-(4-hydroxyhexyl)piperidine；6-(1-piperidinyl)-3-hexanol；6-Piperidin-1-ylhexan-3-ol
• CAS: 114105-72-5
• 化学式: C₁₁H₂₃NO
• 分子量: 185.31
• InChiKey: OPLYZZLKRSUXMK-UHFFFAOYSA-N

物化性质

• 沸点：
  134-136 °C(Press: 22 Torr)
• 密度：
  0.931±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-氧代己酸 在 lithium aluminium tetrahydride 、 氯化亚砜 作用下， 生成 6-(哌啶-1-基)己烷-3-醇
  参考文献：
  名称：

  Kafka, Stanislav; Kytner, Jan; Silhankova, Alexandra, Collection of Czechoslovak Chemical Communications, 1987, vol. 52, # 8, p. 2035 - 2046

  摘要：

  DOI：

文献信息

• Efficient and Regioselective Ruthenium-catalyzed Hydro-aminomethylation of Olefins
  作者：Lipeng Wu、Ivana Fleischer、Ralf Jackstell、Matthias Beller

  DOI：10.1021/ja312271c

  日期：2013.3.13

  An efficient and regioselective ruthenium-catalyzed hydroaminomethlyation of olefins is reported. Key to success is the use of specific 2-phosphino-substituted imidazole ligands and triruthenium dodecacarbonyl as catalyst. Both industrially important aliphatic as well as various functionalized olefins react with primary and secondary amines to give the corresponding secondary and tertiary amines generally in high yields (up to 96%) and excellent regioselectivities (n/iso up to 99:1).
• Amines Made Easily:  A Highly Selective Hydroaminomethylation of Olefins
  作者：Moballigh Ahmed、Abdul Majeed Seayad、Ralf Jackstell、Matthias Beller

  DOI：10.1021/ja030143w

  日期：2003.8.1

  A highly chemo- and regioselective hydroaminomethylation of simple as well as functionalized alpha-olefins using a cationic rhodium precatalyst together with Xantphos as ligand is reported. Studies of the influence of ligands and reaction conditions led to an unprecedented selective hydroaminomethylation procedure. The novel procedure constitutes an economically attractive and environmentally favorable synthesis of secondary and tertiary aliphatic amines.
• KAFKA, S.;KYTNER, J.;SILHANKOVA, A., COLLECT. CZECHOSL. CHEM. COMMUN., 52,(1987) N 8, 2035-2046
  作者：KAFKA, S.、KYTNER, J.、SILHANKOVA, A.

  DOI：——

  日期：——
• PHOSPHOR-LIGANDEN UND VERFAHREN ZUR SELEKTIVEN RUTHENIUM-KATALYSIERTEN HYDROAMINOMETHYLIERUNG VON OLEFINEN
  申请人：Evonik Degussa GmbH

  公开号：EP2951188A1

  公开（公告）日：2015-12-09
• [EN] BENZOTHIOPHENES<br/>[FR] BENZOTHIOPHENES
  申请人：ELI LILLY AND COMPANY

  公开号：WO1999015521A1

  公开（公告）日：1999-04-01

  (EN) This invention is related to novel benzothiophene compounds of formula (I) which are useful for the inhibition of the various medical conditions associated with postmenopausal syndrome, as well as estrogen dependent diseases including cancer of the breast, uterus, and cervix. The present invention further relates to pharmaceutical formulations of compounds of formula (I) and processes for their preparation.(FR) La présente invention concerne de nouveaux composés de benzothiophène répondant à la formule (I) qui sont utilisés pour inhiber différents états pathologiques associés au syndrome postménopausique et à des maladies dépendant des oestrogènes, y compris le cancer du sein, de l'utérus et du col utérin. La présente invention concerne en outre des formulations pharmaceutiques de composés de la formule (I) et leurs procédés de préparation.