2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-2,5-diazabicyclo[2.2.2]octane

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-2,5-diazabicyclo[2.2.2]octane
• 英文别名: 2-(2,3-dihydro-1,4-benzodioxin-6-yl)-2,5-diazabicyclo[2.2.2]octane
• 化学式: C₁₄H₁₈N₂O₂
• 分子量: 246.3
• InChiKey: VJYODSJKXZFSQD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  33.7
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Selective matrix metalloproteinase inhibitors
  申请人：University of Notre Dame du Lac

  公开号：US10253013B2

  公开（公告）日：2019-04-09

  The invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix metalloproteinases (MMPs). The compounds can be selective MMP inhibitors, for example, selective inhibitors of MMP-2, MMP-9, and/or MMP-14. The disease, disorder, or condition can include, for example, stroke, neurological disorders, ophthalmological disorders, or wounds, such as chronic wounds or diabetic wounds.

  本发明提供了用于治疗受基质金属蛋白酶（MMPs）调节的疾病、失调或病症的化合物、组合物和方法。这些化合物可以是选择性 MMP 抑制剂，例如，MMP-2、MMP-9 和/或 MMP-14 的选择性抑制剂。疾病、失调或病症可包括中风、神经失调、眼科失调或伤口，如慢性伤口或糖尿病伤口等。
• SELECTIVE MATRIX METALLOPROTEINASE INHIBITORS
  申请人：University of Notre Dame du Lac

  公开号：US20170015647A1

  公开（公告）日：2017-01-19

  The invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix metalloproteinases (MMPs). The compounds can be selective MMP inhibitors, for example, selective inhibitors of MMP-2, MMP-9, and/or MMP-14. The disease, disorder, or condition can include, for example, stroke, neurological disorders, ophthalmological disorders, or wounds, such as chronic wounds or diabetic wounds.