5-Methyl-4-(4-{[3-(trifluoromethyl)phenyl]sulfonyl}piperazino)thieno[2,3-d]pyrimidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 5-Methyl-4-(4-{[3-(trifluoromethyl)phenyl]sulfonyl}piperazino)thieno[2,3-d]pyrimidine
• 英文别名: 5-methyl-4-[4-[3-(trifluoromethyl)phenyl]sulfonylpiperazin-1-yl]thieno[2,3-d]pyrimidine
• 化学式: C₁₈H₁₇F₃N₄O₂S₂
• 分子量: 442.5
• InChiKey: LNWALPGRCDLEAM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  103
• 氢给体数：
  0
• 氢受体数：
  10

文献信息

• AMINOPYRIMIDINE INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE
  申请人：Borchardt Allen J.

  公开号：US20100063047A1

  公开（公告）日：2010-03-11

  The present invention relates to compounds and methods which may be useful as inhibitors of H 1 R and/or H 4 R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.

  本发明涉及化合物和方法，可能作为H1R和/或H4R的抑制剂用于治疗或预防炎症性、自身免疫性、过敏性和眼部疾病。
• [EN] AMINOPYRIMIDINE INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE<br/>[FR] INHIBITEURS AMINOPYRIMIDINE DES RÉCEPTEURS DE L'HISTAMINE DESTINÉS AU TRAITEMENT D'UNE MALADIE
  申请人：KALYPSYS INC

  公开号：WO2010030757A2

  公开（公告）日：2010-03-18

  The present invention relates to compounds and methods which may be useful as inhibitors of HiR and/or H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.
• [EN] NRF2 SMALL MOLECULE INHIBITORS FOR CANCER THERAPY<br/>[FR] INHIBITEURS DE NRF2 À PETITE MOLÉCULE POUR TRAITEMENT ANTICANCÉREUX
  申请人：UNIV JOHNS HOPKINS

  公开号：WO2014145642A2

  公开（公告）日：2014-09-18

  Small molecule inhibitors of Nrf2 and methods of their use are provided for treating or preventing a disease, disorder or condition associated with an Nrf2- regulated pathway. The compound can be administered as a single agent or can be administered to enhance the efficacy of a chemotherapeutic drug and/or radiation therapy.