2-(4-Benzylpiperazin-1-yl)-5-nitropyrimidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-(4-Benzylpiperazin-1-yl)-5-nitropyrimidine
• 化学式: C15H17N5O2
• 分子量: 299.33
• InChiKey: RUFVROLLFUTCMK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  78.1
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• Bioisosteric bensamide derivatives and their use as apob-100 secretion inhibitors
  申请人：——

  公开号：US20040009988A1

  公开（公告）日：2004-01-15

  The present invention relates to A compound of formula (I) wherein A, U, V, X, Z, R 1 , Y, R 2 and R 3 are defined in the description or a physiologically acceptable salt, solvate or derivative thereof, to compositions and processes for making said compounds and their use in treating conditions ameliorated by an apoB-100 and/or MTP inhibitor. 1

  本发明涉及一种化合物，其化学式为（I），其中A、U、V、X、Z、R1、Y、R2和R3在说明中有定义，或其生理上可接受的盐、溶剂或衍生物，以及制备所述化合物的组合物和方法，以及它们在治疗由apoB-100和/或MTP抑制剂改善的状况中的应用。
• BIOISOSTERIC BENZAMIDE DERIVATIVES AND THEIR USE AS APOB-100 SECRETION INHIBITORS
  申请人：GLAXO GROUP LIMITED

  公开号：EP1289982A1

  公开（公告）日：2003-03-12
• [EN] BIOISOSTERIC BENZAMIDE DERIVATIVES AND THEIR USE AS APoB-100 SECRETION INHIBITORS<br/>[FR] DERIVES DE BENZAMIDE BIO-ISOSTERIQUES ET LEUR UTILISATION COMME INHIBITEURS DE SECRETION D'APOB-100
  申请人：GLAXO GROUP LTD

  公开号：WO2001096327A1

  公开（公告）日：2001-12-20

  The present invention relates to A compound of formula (I) wherein A, U, V, X, Z, R?1, Y, R2 and R3¿ are defined in the description or a physiologically acceptable salt, solvate or derivative thereof, to compositions and processes for making said compounds and their use in treating conditions ameliorated by an apoB-100 and/or MTP inhibitor.