1-(3-Chlorophenyl)-4-[3-[5-(trifluoromethyl)pyridin-2-yl]sulfanylpropyl]piperazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-(3-Chlorophenyl)-4-[3-[5-(trifluoromethyl)pyridin-2-yl]sulfanylpropyl]piperazine
• 化学式: C₁₉H₂₁ClF₃N₃S
• 分子量: 415.9
• InChiKey: BIFJYLKRBXGSMK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  44.7
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATMENT OF PROTEINOPATHIES
  申请人：Washington University

  公开号：US20210228591A1

  公开（公告）日：2021-07-29

  The present disclosure relates generally compositions and methods of using the same for the treatment of proteinopathies (e.g. Alpha-1-antitrypsin deficiency, Non-alcoholic fatty liver disease, Alzheimer's disease, Parkinson's disease, Amyotrophic Lateral Sclerosis, and Huntington's disease) with one or more proteotoxicity reducing agents.
• [EN] COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATMENT OF PROTEINOPATHIES<br/>[FR] COMPOSITIONS ET PROCÉDÉS D'UTILISATION DE CELLES-CI POUR LE TRAITEMENT DE PROTÉINOPATHIES
  申请人：UNIV WASHINGTON

  公开号：WO2019204764A1

  公开（公告）日：2019-10-24

  The present disclosure relates generally compositions and methods of using the same for the treatment of proteinopathies (e.g. Alpha-1-antitrypsin deficiency, Non-alcoholic fatty liver disease, Alzheimer's disease, Parkinson's disease, Amyotrophic Lateral Sclerosis, and Huntington's disease) with one or more proteotoxicity reducing agents.