2-(2-methylaminoethanesulfonyl)ethanol | 193146-01-9

• 分子结构分类: 有机化合物 - 有机硫化合物 - 磺酰类
• 英文名称: 2-(2-methylaminoethanesulfonyl)ethanol
• 英文别名: 2-[[2-(Methylamino)ethyl]sulfonyl]ethanol；2-[2-(methylamino)ethylsulfonyl]ethanol
• CAS: 193146-01-9
• 化学式: C₅H₁₃NO₃S
• 分子量: 167.229
• InChiKey: JBWDJFXHPCIAGI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  74.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(2-methylaminoethanesulfonyl)ethanol 、 4-[5-[(1S)-1-[[2-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoyl]amino]-2-phenylmethoxyethyl]tetrazol-1-yl]butanoic acid 在 N-羟基-7-氮杂苯并三氮唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Tetrazole based amides as growth hormone secretagogues

  摘要：

  A novel series of N1 substituted tetrazole amides were prepared and showed to be potent growth hormone (GH) secretagogues. Among them, hydroxyl containing analog 31 displayed excellent in vivo activity by increasing plasma GH 10-fold in an anesthetized IV rat model. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.03.059

文献信息

• [EN] FLUORESCENT REACTIVE DYES, PROCESS FOR THE PRODUCTION THEREOF AND THEIR USE<br/>[FR] COLORANTS RÉACTIFS FLUORESCENTS, PROCÉDÉ DE PRODUCTION ET UTILISATION DE CEUX-CI
  申请人：DYSTAR COLOURS DISTRIB GMBH

  公开号：WO2015158574A1

  公开（公告）日：2015-10-22

  The present invention is directed to fluorescent reactive dyes of general formula (I) a process for the production thereof and their use.

  本发明涉及一般式（I）的荧光反应染料、其生产方法及其用途。
• Tetrazole based amides as growth hormone secretagogues
  作者：James J. Li、Haixia Wang、Jun Li、Fucheng Qu、Stephen G. Swartz、Andrés S. Hernández、Scott A. Biller、Jeffrey A. Robl、Joseph A. Tino、Dorothy Slusarchyk、Ramakrishna Seethala、Paul Sleph、Mujing Yan、Gary Grover、Neil Flynn、Brian J. Murphy、David Gordon

  DOI：10.1016/j.bmcl.2008.03.059

  日期：2008.4

  A novel series of N1 substituted tetrazole amides were prepared and showed to be potent growth hormone (GH) secretagogues. Among them, hydroxyl containing analog 31 displayed excellent in vivo activity by increasing plasma GH 10-fold in an anesthetized IV rat model. (c) 2008 Elsevier Ltd. All rights reserved.