1-[6-[[[[[[5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]amino]methylamino]-6-oxohexyl]-2-[3-[1-ethyl-3,3-dimethyl-5-(trioxidanylsulfanyl)indol-2-ylidene]prop-1-enyl]-3,3-dimethylindol-1-ium-5-sulfonic acid

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 英文名称: 1-[6-[[[[[[5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]amino]methylamino]-6-oxohexyl]-2-[3-[1-ethyl-3,3-dimethyl-5-(trioxidanylsulfanyl)indol-2-ylidene]prop-1-enyl]-3,3-dimethylindol-1-ium-5-sulfonic acid
• 化学式: C42H57N9O20P3S2+
• 分子量: 1165.0
• InChiKey: KWVGAXPREVXFIK-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  76
• 可旋转键数：
  24
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  449
• 氢给体数：
  11
• 氢受体数：
  24

文献信息

• Fluorescent Nucleotide Analogues
  申请人：Briggs Samuel Mark

  公开号：US20070287162A1

  公开（公告）日：2007-12-13

  The present invention provides fluorescent cyanine dye-based nucleotide analogues, in which the cyanine dye is coupled to the γ-phosphate group of a nucleoside triphosphate. Preferred embodiments of the invention are directed to fluorescent cyanine dye-based GTP analogues which may be employed in an homogeneous FRET-based assay to measure the binding of guanine nucleotides to GPCR polypeptides, or alternatively, to measure the effect of an exogenous ligand on GPCR protein binding.
• US7445902B2
  申请人：——

  公开号：US7445902B2

  公开（公告）日：2008-11-04