(2S,5S)-1,2,4,5-tetramethylpiperazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (2S,5S)-1,2,4,5-tetramethylpiperazine
• 化学式: C₈H₁₈N₂
• 分子量: 142.24
• InChiKey: ZKZVTFXTQPDVLR-YUMQZZPRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Inhibitors of Histone Deacetylase
  申请人：Deziel Robert

  公开号：US20080207590A1

  公开（公告）日：2008-08-28

  This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula (I) wherein Q, J, L and Z are as defined in the specification.

  该发明涉及用于抑制组蛋白去乙酰化酶的化合物。更具体地，该发明提供了式（I）中Q、J、L和Z所定义的化合物。
• SUBSTITUTED- 1H-BENZO[D]IMIDAZOLE SERIES COMPOUNDS AS LYSINE-SPECIFIC DEMETHYLASE 1 (LSD1) INHIBITORS
  申请人：University of Utah

  公开号：US20150065495A1

  公开（公告）日：2015-03-05

  The present invention provides compounds which are useful as inhibitors of lysine-specific demethylase 1 (“LSD1”). The present invention also relates to pharmaceutical compositions containing these compounds. The present invention also relates to a method for preparing these compounds. The present invention also relates to a method of treating a mammalian disorder in which LSD1 levels are elevated by administering these compounds and compositions to a patient in need thereof. The present invention also relates to a method for decreasing histone demethylase activity in a mammal comprising administering to the mammal an effective amount of these compounds and compositions.

  本发明提供了一些化合物，这些化合物可用作赖氨酸特异性去甲基化酶1（“LSD1”）的抑制剂。本发明还涉及含有这些化合物的制药组合物。本发明还涉及制备这些化合物的方法。本发明还涉及通过向需要治疗的患者给予这些化合物和组合物来治疗LSD1水平升高的哺乳动物疾病的方法。本发明还涉及一种降低哺乳动物组织中组蛋白去甲基化酶活性的方法，包括向哺乳动物中施用这些化合物和组合物的有效量。
• Substituted benzohydrazide analogs as histone demethylase inhibitors
  申请人：University of Utah Research Foundation

  公开号：US20170001970A1

  公开（公告）日：2017-01-05

  Benzohydrazide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of lysine-specific histone demethylase, including LSD1 and LSD2; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the LSD1 and/or LSD2.
• US8399452B2
  申请人：——

  公开号：US8399452B2

  公开（公告）日：2013-03-19