(4-chlorophenyl)(4-(2-nitrophenyl)piperazin-1-yl)methanone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (4-chlorophenyl)(4-(2-nitrophenyl)piperazin-1-yl)methanone
• 英文别名: (4-Chlorophenyl)[4-(2-nitrophenyl)piperazin-1-yl]methanone；(4-chlorophenyl)-[4-(2-nitrophenyl)piperazin-1-yl]methanone
• 化学式: C₁₇H₁₆ClN₃O₃
• 分子量: 345.785
• InChiKey: WYZYJZPSRVUTEC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  69.4
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• PIPERIDINYL- AND PIPERAZINYL-SUBSTITUTED HETEROAROMATIC CARBOXAMIDES AS MODULATORS OF GPR6
  申请人：TAKEDA PHARMACEUTICAL COMPANY LIMITED

  公开号：US20200375969A1

  公开（公告）日：2020-12-03

  Disclosed are compounds of Formula 1 and pharmaceutically acceptable salts thereof, wherein L, R 4 , R 5 , R 8 , R 10 , R 11 , X 1 , X 2 , X 3 , X 9 , X 12 , and Z are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, to pharmaceutical compositions which contain them, and to their use for treating diseases, disorders, and conditions associated with GPR6.