1-{2-Fluoro-4-nitro-5-[4-(phenylsulfonyl)piperazin-1-yl]phenyl}azepane

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-{2-Fluoro-4-nitro-5-[4-(phenylsulfonyl)piperazin-1-yl]phenyl}azepane
• 英文别名: 1-[5-[4-(benzenesulfonyl)piperazin-1-yl]-2-fluoro-4-nitrophenyl]azepane
• 化学式: C22H27FN4O4S
• mdl: MFCD03143154
• 分子量: 462.5
• InChiKey: PHTDYGXLLYTXFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  98.1
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• Inhibitors of GPR174 and Uses Thereof
  申请人：Omeros Corporation

  公开号：US20200276190A1

  公开（公告）日：2020-09-03

  GPR174 is an orphan receptor that has been implicated in cancer, nervous system diseases and disorders and neuroregeneration. We have identified inhibitors of GPR174 and have identified the G-protein signaling pathways that GPR174 modulates. Based on this discovery, the present invention features methods for inhibiting GPR174 activity and thereby stimulating an immune response in a subject in need thereof, particularly in the use of treatment of non-malignant neoplasms, malignant neoplasms (i.e., cancer), nervous system diseases and disorders and neuroregeneration, as well as related compositions.
• Methods and Compositions for Treating Cancer
  申请人：Omeros Corporation

  公开号：US20200345725A1

  公开（公告）日：2020-11-05

  This disclosure is directed to compounds, compositions, and methods for the treatment of various diseases and/or conditions related to G protein-coupled receptor 174 (e.g., cancers).