3-(3-amino-2-hydroxypropyl)-N-[1-[4-[1-[3-(3-amino-2-hydroxypropyl)octadec-9-enoylamino]-2-hydroxypropyl]piperazin-1-yl]-2-hydroxypropyl]octadec-9-enamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 3-(3-amino-2-hydroxypropyl)-N-[1-[4-[1-[3-(3-amino-2-hydroxypropyl)octadec-9-enoylamino]-2-hydroxypropyl]piperazin-1-yl]-2-hydroxypropyl]octadec-9-enamide
• 化学式: C₅₂H₁₀₂N₆O₆
• 分子量: 907.4
• InChiKey: YUIUUTDMESBBPW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.9
• 重原子数：
  64
• 可旋转键数：
  42
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  198
• 氢给体数：
  8
• 氢受体数：
  10

文献信息

• [EN] AGENTS FOR IMPROVED DELIVERY OF NUCLEIC ACIDS TO EUKARYOTIC CELLS<br/>[FR] AGENTS PERMETTANT D'AMÉLIORER L'ADMINISTRATION D'ACIDES NUCLÉIQUES DANS DES CELLULES EUCARYOTES
  申请人：MOLECULAR TRANSFER INC

  公开号：WO2013158127A1

  公开（公告）日：2013-10-24

  New cationic lipids are provided that are useful for delivering macromolecules, such as nucleic acids, into eukaryotic cells. The lipids can be used alone, in combination with other lipids and/or in combination with other transfection enhancing reagents to prepare transfection complexes.

  提供了新的阳离子脂质，可用于将大分子（如核酸）传递到真核细胞中。这些脂质可以单独使用，与其他脂质和/或其他转染增强试剂结合使用，以制备转染复合物。
• [EN] AGENTS FOR IMPROVED DELIVERY OF NUCLEIC ACIDS TO EUKARYOTIC CELLS<br/>[FR] AGENTS POUR UNE ADMINISTRATION AMÉLIORÉE D'ACIDES NUCLÉIQUES À DES CELLULES EUCARYOTES
  申请人：MOLECULAR TRANSFER INC

  公开号：WO2012142622A1

  公开（公告）日：2012-10-18

  New cationic lipids are provided that are useful for delivering macromolecules, such as nucleic acids, into eukaryotic cells. The lipids can be used alone, in combination with other lipids and/or in combination with other transfection enhancing reagents to prepare transfection complexes.

  提供了新的阳离子脂质，可用于将大分子（如核酸）传递到真核细胞中。这些脂质可以单独使用，与其他脂质和/或其他转染增强试剂结合使用，制备转染复合物。
• TRINUCLEOTIDE CAP ANALOGS, PREPARATION AND USES THEREOF
  申请人：LIFE TECHNOLOGIES CORPORATION

  公开号：US20220002716A1

  公开（公告）日：2022-01-06

  This specification generally relates to trinucleotide RNA cap analogs, methods of use thereof, and kits comprising same. In particular, the trinucleotide cap analogs provided herein permit ready detection and/or isolation of capped RNA transcripts in vitro and translation of capped mRNAs in vivo.

  该规范通常涉及三核苷酸RNA帽类似物，其使用方法以及包含相同的试剂盒。具体来说，本文提供的三核苷酸帽类似物可方便地检测和/或分离体外带帽RNA转录本，并在体内翻译带帽mRNA。
• Novel reagents for transfection of eukaryotic cells
  申请人：Jessee Joel

  公开号：US20090023215A1

  公开（公告）日：2009-01-22

  Compositions and methods for improved delivery of macromolecules into eukaryotic cells are provided. Fusogenic peptides from fusion proteins of non-enveloped viruses enhance the efficiency of transfection of eukaryotic cells mediated by transfection agents such as cationic lipids, polycationic polymers such as PEI and dendrimers. These fusogenic peptides are used as part of a transfection complex that efficiently delivers a macromolecule, for example, a nucleic acid, into a eukaryotic cell. Novel cationic lipids and compositions of cationic lipids also are provided that may be used for the introduction of macromolecules such as nucleic acids, proteins and peptides into a variety of cells and tissues. The lipids can be used alone, in combination with other lipids and/or in combination with fusogenic peptides to prepare transfection complexes.

  本发明提供了用于改进将大分子传递到真核细胞的组合物和方法。来自非包膜病毒融合蛋白的融合肽增强了由阳离子脂质、多阳离子聚合物（如PEI）和树状分子等转染剂介导的真核细胞转染效率。这些融合肽作为转染复合物的一部分，有效地将大分子（例如核酸）传递到真核细胞中。本发明还提供了新型阳离子脂质和阳离子脂质组合物，可用于将大分子（如核酸、蛋白质和肽）引入各种细胞和组织中。这些脂质可以单独使用，与其他脂质结合使用和/或与融合肽结合使用以制备转染复合物。
• NOVEL REAGENTS FOR TRANSFECTION OF EUKARYOTIC CELLS
  申请人：Jessee Joel

  公开号：US20120052574A1

  公开（公告）日：2012-03-01

  Compositions and methods for improved delivery of macromolecules into eukaryotic cells are provided. Fusogenic peptides from fusion proteins of non-enveloped viruses enhance the efficiency of transfection of eukaryotic cells mediated by transfection agents such as cationic lipids, polycationic polymers such as PEI and dendrimers. These fusogenic peptides are used as part of a transfection complex that efficiently delivers a macromolecule, for example, a nucleic acid, into a eukaryotic cell. Novel cationic lipids and compositions of cationic lipids also are provided that may be used for the introduction of macromolecules such as nucleic acids, proteins and peptides into a variety of cells and tissues. The lipids can be used alone, in combination with other lipids and/or in combination with fusogenic peptides to prepare transfection complexes.

  提供了一种改进大分子进入真核细胞的组合物和方法。来自非包膜病毒融合蛋白的融合肽增强了由阳离子脂质、聚阳离子聚合物（如PEI）和树状分子等转染剂介导的真核细胞转染的效率。这些融合肽作为转染复合物的一部分，有效地将大分子（例如核酸）传递到真核细胞中。还提供了新型阳离子脂质和阳离子脂质组合物，可用于将大分子（如核酸、蛋白质和肽）引入各种细胞和组织中。这些脂质可以单独使用，与其他脂质结合使用和/或与融合肽结合使用以制备转染复合物。