Lu 37-211 | 765890-60-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: Lu 37-211
• 英文别名: 4-(3-(4-(3-(5-fluoro-1H-indol-3-yl)propyl)piperazin-1-yl)-2-methylphenyl)morpholine；4-[3-[4-[3-(5-fluoro-1H-indol-3-yl)propyl]piperazin-1-yl]-2-methylphenyl]morpholine
• CAS: 765890-60-6
• 化学式: C₂₆H₃₃FN₄O
• 分子量: 436.573
• InChiKey: MURVARKHGHKPSP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  34.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-(2-Methyl-3-piperazin-1-ylphenyl)morpholine 、 3-(3-溴丙基)-5-氟-1H-吲哚 在 N,N-二异丙基乙胺 作用下， 以 乙腈 为溶剂， 反应 24.0h， 以1.22 g的产率得到Lu 37-211
  参考文献：
  名称：

  Palladium-catalyzed monoamination of dihalogenated benzenes

  摘要：

  The palladium-catalyzed monoamination of symmetric dibromobenzenes can be performed using a catalyst based on Pd(2)dba(3) and BINAP in the presence of NaO(t-Bu). The analogous transformation of non-symmetric bromoiodobenzenes is most effectively performed with Xantphos as the ligand, while reactions with BINAP were non-selective. These transformations can be scaled uneventfully to >10 g quantities. They do not require drybox or Schlenk techniques, and all reagents are weighed out in air. The resulting monobromoanilines are versatile intermediates for further synthetic transformations. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.01.070

文献信息

• Phenylpiperazinyl derivatives
  申请人：H. Lundbeck A/S

  公开号：US20030083336A1

  公开（公告）日：2003-05-01

  The present invention relates to a novel class of substituted phenylpiperazinyl derivatives having the formula 1 wherein X, Z, Y, U, V, Alk, W, R 1 , R 2 , R 3 , R 11 , R 12 , R 13 n, m and the dotted line are as define in the description. The compounds of the invention are dopamine D 4 receptor ligands and are therefore useful for the treatment of certain psychiatric and neurologic disorders, including psychosis.

  本发明涉及一种新型的取代苯基哌嗪衍生物，其具有以下式子1： 其中X，Z，Y，U，V，Alk，W，R1，R2，R3，R11，R12，R13n，m和虚线如描述中所定义。 该发明中的化合物是多巴胺D4受体配体，因此可用于治疗某些精神和神经疾病，包括精神病。
• PHENYLPIPERAZINYL DERIVATIVES
  申请人：H. Lundbeck A/S

  公开号：EP1246815B1

  公开（公告）日：2004-03-17
• [EN] PHENYLPIPERAZINYL DERIVATIVES<br/>[FR] DERIVES DE PHENYLPIPERAZINYLE
  申请人：LUNDBECK & CO AS H

  公开号：WO2001049677A1

  公开（公告）日：2001-07-12

  The present invention relates to a novel class of substituted phenylpiperazinyl derivatives having the formula (I) wherein X, Z, Y, U,V, Alk, W, R?1 , R2, R3, R11, R12, R13¿ n, m and the dotted line are as defined in the description. The compounds of the invention are dopamine D¿4? receptor ligands and are therefore useful for the treatment of certain psychiatric and neurologic disorders, including psychosis.
• Palladium-catalyzed monoamination of dihalogenated benzenes
  作者：Simon Birksø Larsen、Benny Bang-Andersen、Tommy Nørskov Johansen、Morten Jørgensen

  DOI：10.1016/j.tet.2008.01.070

  日期：2008.3

  The palladium-catalyzed monoamination of symmetric dibromobenzenes can be performed using a catalyst based on Pd(2)dba(3) and BINAP in the presence of NaO(t-Bu). The analogous transformation of non-symmetric bromoiodobenzenes is most effectively performed with Xantphos as the ligand, while reactions with BINAP were non-selective. These transformations can be scaled uneventfully to >10 g quantities. They do not require drybox or Schlenk techniques, and all reagents are weighed out in air. The resulting monobromoanilines are versatile intermediates for further synthetic transformations. (C) 2008 Elsevier Ltd. All rights reserved.